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- Table of Contents
Integrin beta-2 Antibodies
AND ITGB2 ELISA kits, Integrin beta-2 Proteins
Many biological assays use antibodies to detect Integrin beta-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin beta-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin beta-2 antibodies...
Designing a Western blot for Integrin beta-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ITGB2 Western Blot GuideITGB2 Infographic by Boster Bio
All ITGB2 Products
Product
Figures
Specificity
Applications
Price
Human
IHC, WB
$370
Cat # M00458-1
100 μg/vial
Cat # M00458-1
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01102-3
100 μg
Cat # M01102-3
100 μg
Human
Flow Cytometry, IP, IHC-P, IHC-F, WB
$299
Cat # M00458-2
0.1 mg
Cat # M00458-2
0.1 mg
Mouse
Flow Cytometry, IP, IHC-P, IHC-F, WB
$299
Cat # M00458-3
0.1 mg
Cat # M00458-3
0.1 mg
ITGB2 Overview
Facts about Integrin beta-2.
Integrin beta-2 (ITGB2)
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4.
Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen.Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain.
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGB2 |
| Uniprot: | P05107 |
| Entrez: | 3689 |
Family
| Belongs to: |
|---|
| integrin beta chain family |
Alternative Names
959 beta subunit precursor)10; CD18 antigen; CD18; CD18beta 2; cell surface adhesion glycoprotein (LFA-1; CR3; Integrin beta 2; integrin beta-2; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITGB2; LAD; LCAMB; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; LFA-1 beta; LFA-1; MAC-1 beta; MF17; MFI7; P150; p150,95 beta
Molecular Weight
Mass (kDA):
84.782 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.3 |
| Sequence: | 21; NC_000021.9 (44885949..44928815, complement) |
Tissue Specificity
Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein.
Diseases
- Tissue Adhesions
- Leukocyte Adhesion Deficiency
- Leukocyte-adhesion Deficiency Syndrome
- Malignant Neoplasms
- Neoplasms
- Dog Diseases
- Inflammation
- Immunologic Deficiency Syndromes
- Infective Disorder
- Carcinogenesis
- Ulcer
- Atherosclerosis
- Diabetes Mellitus
Interacting Proteins
- ABL1
- ITGAX
- NOTCH2NL
- RDX
- TLN2
Pathways
- Immune Response
- Cell Adhesion
- Wound Healing
- Cell Proliferation
- Pathogenesis
- Inflammatory Response
- Localization
- Secretion
- Cell Activation
- Fertilization
- Hepatocyte Proliferation
- Platelet Aggregation
- Menstruation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGB2
bosterbio.com/bosterbio-gene-info-cards/ITGB2
References
PMID: 3028646 by Kishimoto T.K., et al. Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family.
PMID: 1683838 by Weitzman J.B., et al. The gene organisation of the human beta 2 integrin subunit (CD18).
1 Publications of Boster Integrin beta-2 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.bbrc.2016.10.049, Identification of THY1 as a novel thyrotrope marker and THY1 antibody-mediated t...
*More publications can be found for each product on its corresponding product page