Anti-CD18/ITGB2 Antibody Picoband™

Integrin beta 2/CD18 antibody

Boster Bio Anti-CD18/ITGB2 Antibody Picoband™ catalog # PB9141. Tested in IF, IHC, WB applications. This antibody reacts with Human. Cited in 1 publication(s).

Product Info Summary

SKU: PB9141
Size: 100 μg/vial
Reactive Species: Human
Host: Rabbit
Application: IF, IHC, WB

Product Name

Anti-CD18/ITGB2 Antibody Picoband™

View all Integrin beta 2/CD18 Antibodies

SKU/Catalog Number

PB9141

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-CD18/ITGB2 Antibody Picoband™ catalog # PB9141. Tested in IF, IHC, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CD18/ITGB2 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9141)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human CD18 recombinant protein (Position: Q404-S769). Human CD18 shares 76% amino acid (aa) sequence identity with mouse CD18.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9141 is reactive to ITGB2 in Human

Applications

PB9141 is guaranteed for IF, IHC, WB Boster Guarantee

Observed Molecular Weight

90-100 kDa

Calculated molecular weight

84.782kDa

Background of Integrin beta 2/CD18

ITGB2 (INTEGRIN, BETA-2), also known as CD18, is a protein that in humans is encoded by the ITGB2 gene. ITGB2 is an integrin protein that belongs to the class of cell membrane glycoproteins. The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated CD18. The ITGB2 gene is mapped to 21q22.3. The expression of CD18 is increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 21. In humans lack of ITGB2 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. Although ITGB2 is expressed on the cell surface at normal levels and is capable of function following extracellular stimulation, it could not be activated via the 'inside-out' signaling pathways.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, By Heat
Immunofluorescence, 5μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For ITGB2 (Source: Uniprot.org, NCBI)

Gene Name

ITGB2

Full Name

Integrin beta-2

Weight

84.782kDa

Superfamily

integrin beta chain family

Alternative Names

959 beta subunit precursor)10; CD18 antigen; CD18; CD18beta 2; cell surface adhesion glycoprotein (LFA-1; CR3; Integrin beta 2; integrin beta-2; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITGB2; LAD; LCAMB; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; LFA-1 beta; LFA-1; MAC-1 beta; MF17; MFI7; P150; p150,95 beta ITGB2 CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin subunit beta 2 integrin beta-2|cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)|complement component 3 receptor 3 and 4 subunit|complement receptor C3 beta-subunit|integrin beta chain, beta 2|integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)|leukocyte cell adhesion molecule CD18|leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C|truncated integrin beta-2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ITGB2, check out the ITGB2 Infographic

ITGB2 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ITGB2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PB9141 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Identification of THY1 as a novel thyrotrope marker and THY1 antibody-mediated thyrotrope isolation in the rat anterior pituitary gland

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1 Customer Q&As for Anti-CD18/ITGB2 Antibody Picoband™

Question

We are currently using anti-CD18/ITGB2 antibody PB9141 for human tissue, and we are content with the Flow Cytometry results. The species of reactivity given in the datasheet says human. Is it possible that the antibody can work on pig tissues as well?

M. Wu

Verified customer

Asked: 2016-02-11

Answer

The anti-CD18/ITGB2 antibody (PB9141) has not been validated for cross reactivity specifically with pig tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in pig you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2016-02-11

Order DetailsPrice
PB9141

100μg

$370
PB9141-10ug

10μg sample (liquid)

$99
PB9141-Biotin

100 μg Biotin conjugated

$570
PB9141-Cy3

100 μg Cy3 conjugated

$570
PB9141-Dylight488

100 μg Dylight488 conjugated

$570
PB9141-Dylight550

100 μg Dylight550 conjugated

$570
PB9141-Dylight594

100 μg Dylight594 conjugated

$570
PB9141-FITC

100 μg FITC conjugated

$570
PB9141-HRP

100 μg HRP conjugated

$570
PB9141-APC

100 μg APC conjugated

$670
PB9141-PE

100 μg PE conjugated

$670
PB9141-carrier-free

Carrier Free

$370

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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