Kit ligand (KITLG)

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an important role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell growth, function and migration, and in melanogenesis.

KITLG/SCF binding may activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of this kinase AKT1.