Neurotrophin-3 Antibodies

Neurotrophin-3 (NTF3)

Seems to promote the survival of visceral and proprioceptive sensory neurons. .

Gene Information

Human
Gene Name:	NTF3
Uniprot:	P20783
Entrez:	4908

Family

Belongs to:
NGF-beta family

Alternative Names

HDNF; MGC129711; Nerve growth factor 2; Neurotrophic factor; neurotrophin 3; neurotrophin-3; NGF2; NGF-2; NT3; NT-3; NTF3

Molecular Weight

Mass (kDA):
29.355 kDA

Genomic Context

Human
Location:	12p13.31
Sequence:	12; NC_000012.12 (5432108..5495299)

Tissue Specificity

Brain and peripheral tissues.

Subcellular Localizations

Secreted.

Diseases

• Nervousness
• Attention Deficit Hyperactivity Disorder
• Dysequilibrium Syndrome
• Malnutrition
• Schizophrenia
• Cholangiocarcinoma
• Neoplasm Metastasis
• Malignant Neoplasm Of Breast
• Adolescent Idiopathic Scoliosis
• Glioma
• Glaucoma, Open-angle

• Neuronal Migration Disorders
• Infertility
• Malignant Neoplasms
• Neoplasms
• Scoliosis, Unspecified
• 5,10-methylenetetrahydrofolate Reductase Deficiency

Interacting Proteins

• MEOX2
• Ngfr

Pathways

• Pathogenesis
• Transport
• Cell Migration
• Sex Determination
• Cell Division
• Cell Differentiation
• Innervation
• Cell Adhesion
• Sertoli Cell Differentiation
• Fertilization
• Brain Development
• Eating Behavior
• Leydig Cell Differentiation

• Ovule Development
• Spermatogenesis
• Reflex
• Autocrine Signaling
• Translation
• Gliogenesis
• Gonad Development

PTMs

• Phosphorylation

• Cleavage

• Methylation

Research Areas

• Apoptosis
• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NTF3

Boster Bio - Best Uses Of The NTF3 Marker

The NTF3 marker protein is versatile. Its applications range from basic research to clinical trials. In this article, we'll go over its cost, the significance of its biological function, and clinical applications. Continue reading to find out more about the best uses of this protein. Then, you can compare it with other biomarkers in the same class. And, remember that Boster's NTF3 protein is accessible to all scientists in the world.

Biological significance

In a prior study, the NTF3 marker was found to be correlated with the immune cells that comprise a subset of NK cells found in HCC patients. We also found that NTF3 expression was strongly correlated with the presence activated B cells, TH2 cells, and mast cells. These cells had the strongest correlation with NTF3 expression Our study demonstrated that the expression of NTF3 was related with the degree of immune infiltration.

Our study also revealed that the expression of long non-coding RNAs (lnc-NTF3-5) affected the osteogenic differentiation of MSMSCs. We employed a combination of real-time PCR in quantitative manner, Osterix (OSX), and Alkaline Phosphatase (ALP) to determine the levels of expression of lnc-NTF3-5. Additionally, we analyzed the functional aspects of the gene by using a loss-of-function (lnc-NTF3-5) assay Western blot, western blot and Alizarin Red staining. We also assessed the microRNA sponge potency of lnc–NTF3-5 with an immunoprecipitation technique for RNA.

We know that Ntf3 is present throughout the cerebral cortex. We also know that Ntf3 promotes premature differentiation in UL progenitors. Therefore, we have a better understanding of the mechanisms that control its expression. This review is a great place to start if you are interested in studying this marker. The authors offer further sources to further studies. All authors declare that their research results are reliable and objective.

The NTF3 gene is closely associated with the neurotrophin family. NTF3 is a key factor in the survival of neurons of the neural crest subset, and induces neurite growth in neurons derived via placodes. It also regulates the development of neural crest progenitor cells. The NTF3 gene is extensively expressed in the adult human brain. These findings confirm the importance of NTF3 gene and protein in maintaining the adult nervous system.

The lnc-NTF3-5 gene regulates miR93-3p. It is vital for the proper functioning of miR-93-3p as well as its target gene RUNX2 in cancer. These studies can help reveal the biological significance of the NTF3 marker, as well as the target gene expression. The NTF3 gene has numerous benefits in cancer research and could be vital to the development of new treatments.

Clinical applications

A new research study utilizes the NTF3 marker as a biomarker to detect the beginning of a new cancer. The expression of this protein is an option for treating cancer. The overexpression of Ntf3 in mice stopped the loss of synaptic synaptic membranes after exposure to noise. These synaptic ribbons were further reduced between 2 hours and 14 day after exposure.

In mice, overexpression of Ntf3 results in the regeneration of synaptic contacts. This process could be linked to the pathogenesis of noise-induced synaptopathy, an illness that causes damage to cochlear nerves. Noise-induced synaptopathy results in hair cells being damaged and permanent threshold changes in the auditory pathway. Numerous studies have also demonstrated an unfavorable relationship between Ntf3 overexpression and the development of Acoustic neuropathy.

Overexpression of Ntf3 increases the number of synapses. However, Ntf3 expression is restricted in neurons, and the overexpression may increase the number synapses. The neurotrophic hypothesis for NTF3 gene suggests that the protein is only expressed in a small number of neurons. This finding could be an effective therapeutic target for Ntf3 gene treatments. This discovery also provides insight into the role of Ntf3 gene therapy in the development of therapeutic agents.

Several studies have shown that Ntf3 expression in the cochlea may be associated with cochlea function, as well as the number of synapses. The removal of Ntf3 from supporting cells has the same impact on cochlear functioning. Hair cells that express Ntf3 have similar effects on cochlear sensitivity and cochlear function. This suggests that Ntf3 in the cochlea may be dispensable for normal auditory function.

The Ntf3 protein is a major endogenous source of Ntf3. The protein has been proven to increase synaptic densities of hair cells and the postnatal colea. To determine the biological significance and the function of Ntf3 as a marker for hearing loss, further research is required. Ntf3 is an intriguing candidate for the detection of hearing disorders. Although clinical applications are still in the early stages of development, there are a lot of unanswered questions.

There are a variety of protein molecules that are circulating that could be used as cancer markers. However only 16 demonstrated dysregulation in plasma and tumor tissue. However, only three genes showed the same direction of dysregulation between healthy controls and patients. Neurotrophin-3 was the gene that showed the greatest distinction between SCCT patients and healthy controls. Further research is needed to determine its function in SCCT. These studies will provide the final answer to this long-awaited query.

Cost

In the past, the price of the NTF3 marker was extremely high. It was virtually impossible for patients to afford this test, and it's sometimes difficult to get accurate results without the help of a third party. A simple blood test is now available and does not come with a high price tag. However the price of the NTF3 marker is still affordable compared to the benefits it offers.