BDNF/NT-3 growth factors receptor (NTRK2)

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Alternatively can also bind NTF3/neurotrophin-3 that is less effective in activating the receptor but regulates neuron survival through NTRK2.

Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that govern distinct overlapping signaling cascades.