Prokineticin-1 (PROK1)

Induces proliferation, migration and fenestration (the formation of tissue discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types.

Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma development by promoting the proliferation and migration of neuroblastoma cells.