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- Table of Contents
Prokineticin-1 Antibodies
AND PROK1 ELISA kits, Prokineticin-1 Proteins
Many biological assays use antibodies to detect Prokineticin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prokineticin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prokineticin-1 antibodies...
Designing a Western blot for Prokineticin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PROK1 Western Blot GuidePROK1 Infographic by Boster Bio
All PROK1 Products
Product
Figures
Specificity
Applications
Price
Human EG-VEGF/PK1/PROK1 ELISA Kit PicoKine®
4 Citations
Human
ELISA
$499
Cat # EK0575
96 wells/kit, with removable strips.
Cat # EK0575
96 wells/kit, with removable strips.
Human
$628
Cat # LS084432
20 µg, 100 µg
Cat # LS084432
20 µg, 100 µg
PROK1 Overview
Facts about Prokineticin-1.
Prokineticin-1 (PROK1)
Induces proliferation, migration and fenestration (the formation of tissue discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types.
Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma development by promoting the proliferation and migration of neuroblastoma cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | PROK1 |
| Uniprot: | P58294 |
| Entrez: | 84432 |
Family
| Belongs to: |
|---|
| AVIT (prokineticin) family |
Alternative Names
EGVEGF; EG-VEGF; EGVEGFblack mamba toxin-related protein; Endocrine-gland-derived vascular endothelial growth factor; Mambakine; PK1mambakine; PRK1prokineticin-1; PROK1; Prokineticin 1
Molecular Weight
Mass (kDA):
11.715 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.3 |
| Sequence: | 1; NC_000001.11 (110451149..110457358) |
Tissue Specificity
Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.
Subcellular Localizations
Secreted.
Diseases
- Tumor Angiogenesis
- Endometrial Polyp
- Neoplasms
- Malignant Neoplasms
- Pathologic Neovascularization
- Mycoplasma Pneumonia
- Hypoxia
- Carcinoma
- Ectopic Pregnancy
- Pancreatic Neoplasm
- Tissue Adhesions
- Endometriosis, Site Unspecified
Pathways
- Angiogenesis
- Secretion
- Localization
- Regulation Of Angiogenesis
- Decidualization
- Transport
- Cell Adhesion
- Muscle Contraction
- Inflammatory Response
- Monocyte Activation
- Cell Proliferation
- Smooth Muscle Contraction
- Parturition
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PROK1
bosterbio.com/bosterbio-gene-info-cards/PROK1
References
PMID: 11259612 by Li M., et al. Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle.
PMID: 11528470 by LeCouter J., et al. Identification of an angiogenic mitogen selective for endocrine gland endothelium.
6 Publications of Boster Prokineticin-1 Antibodies & ELISA Kits
- PubMed ID: 10.1167/iovs.14-14734, Knockout of αA-Crystallin Inhibits Ocular Neovascularization
- PubMed ID: 10.1080/14767058.2017.1351536, Use of prokineticin-1 (PROK1), pregnancy-associated plasma protein A (PAPP-A) an...
- PubMed ID: 10.1016/j.placenta.2017.12.015, Relationship between second-trimester amniotic fluid levels of Prokineticin-1 an...
- PubMed ID: -, Efficacy of EP chemotherapy followed by IP chemotherapy combined with radiothera...
- PubMed ID: 28675948, Use of prokineticin-1 (PROK1), pregnancy-associated plasma protein A (PAPP-A) an...
- PubMed ID: 21139695, Administration of pigment epithelium-derived factor delivered by adeno-associate...
*More publications can be found for each product on its corresponding product page