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CARD11 Antibodies
AND CARD11 ELISA kits, CARD11 Proteins
Many biological assays use antibodies to detect CARD11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CARD11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CARD11 antibodies...
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CARD11 Overview
Facts about Caspase recruitment domain-containing protein 11.
Caspase recruitment domain-containing protein 11 (CARD11)
Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner.
Activates NF-kappa-B through BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Gene Information
| Human | |
|---|---|
| Gene Name: | CARD11 |
| Uniprot: | Q9BXL7 |
| Entrez: | 84433 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BIMP3; BIMP3card-maguk protein 1; CARD11; CARD-containing MAGUK protein 1; Carma 1; CARMA1; CARMA1bcl10-interacting maguk protein 3; caspase recruitment domain family, member 11; caspase recruitment domain-containing protein 11; MGC133069
Molecular Weight
Mass (kDA):
133.284 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p22.2 |
| Sequence: | 7; NC_000007.14 (2906075..3043867, complement) |
Tissue Specificity
Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL- 60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.
Subcellular Localizations
Cytoplasm. Membrane raft. Colocalized with DPP4 in membrane rafts.
Diseases
- Lymphoma
- B-cell Lymphomas
- Diffuse Large B-cell Lymphoma
- Neoplasms
- Malignant Neoplasms
- Marginal Zone B-cell Lymphoma
- Mucosa-associated Lymphoid Tissue Lymphoma
- Immunologic Deficiency Syndromes
- Leukemogenesis
- Inflammation
- Autoimmune Diseases
- Cell Transformation, Neoplastic
- Leukemia
Interacting Proteins
- BCL10
- CSNK1A1
- MALT1
- Map4k1
- PRKCD
Pathways
- Cell Activation
- T Cell Activation
- Lymphocyte Activation
- Cytokine Production
- Pathogenesis
- Immune Response
- Adaptive Immune Response
- Cell Proliferation
- Cell Death
- Rna Interference
- Cell Development
- Lymphocyte Proliferation
- B Cell Proliferation
PTMs
- Phosphorylation
- Ubiquitination
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CARD11
bosterbio.com/bosterbio-gene-info-cards/CARD11
References
PMID: 11278692 by Bertin J., et al. CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-kappaB.
PMID: 11356195 by Gaide O., et al. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.