This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
SOCS3 Antibodies
AND SOCS3 ELISA kits, SOCS3 Proteins
Many biological assays use antibodies to detect SOCS3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SOCS3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SOCS3 antibodies...
Designing a Western blot for SOCS3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SOCS3 Western Blot GuideDesigning an IHC experiment for SOCS3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SOCS3 IHC GuideSOCS3 Infographic by Boster Bio
All SOCS3 Products
Product
Figures
Specificity
Applications
Price
Anti-SOCS3 Antibody Picoband®
3 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00274-2
100 μg/vial
Cat # A00274-2
100 μg/vial
SOCS3 Overview
Facts about Suppressor of cytokine signaling 3.
Suppressor of cytokine signaling 3 (SOCS3)
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway.
Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | SOCS3 |
| Uniprot: | O14543 |
| Entrez: | 9021 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ATOD4; CIS3; CIS3CIS-3; Cish3; cytokine-induced SH2 protein 3; Cytokine-inducible SH2 protein 3; SOCS3; SOCS-3; SOCS-3STAT-induced STAT inhibitor 3; SSI-3; SSI-3ATOD4; SSI3MGC71791; suppressor of cytokine signaling 3
Molecular Weight
Mass (kDA):
24.77 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (78356777..78360079, complement) |
Tissue Specificity
Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus.
Diseases
- Inflammation
- Janiceps
- Obesity
- Malignant Neoplasms
- Insulin Resistance
- Neoplasms
- Leukemia
- Diabetes Mellitus
- Hepatitis
- Inflammatory Response
- Carcinoma
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Sensitivity
Interacting Proteins
- GAB1
- KIAA1958
- KIT
- MAP1S
- SNAI1
- YES1
Pathways
- Pathogenesis
- Secretion
- Immune Response
- Cell Proliferation
- Inflammatory Response
- Methylation
- Cytokine Production
- Regeneration
- Cell Differentiation
- Cell Growth
- Lactation
- Energy Homeostasis
- Cell Cycle
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
- Oxidation
- Demethylation
- Dephosphorylation
- Acetylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SOCS3
bosterbio.com/bosterbio-gene-info-cards/SOCS3
References
PMID: 9266833 by Minamoto S., et al. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
PMID: 9344848 by Masuhara M., et al. Cloning and characterization of novel CIS family genes.
2 Publications of Boster SOCS3 Antibodies & ELISA Kits
- PubMed ID: 29228585, Yang M, Tian M, Zhang X, Xu J, Yang B, Yu J, Li F, Li Y, Li S, Li X. Oncotarget....
- PubMed ID: 25695729, Wan J, Che Y, Kang N, Wu W. Mol Med Rep. 2015 Jul;12(1):83-92. Doi: 10.3892/Mmr....
*More publications can be found for each product on its corresponding product page