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Product Info Summary
| SKU: | M00274 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | WB |
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Product info
Product Name
Anti-SOCS3 Purified Monoclonal Antibody
SKU/Catalog Number
M00274
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SOCS3 Purified Monoclonal Antibody (Catalog# M00274). Tested in WB application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-SOCS3 Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00274)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
SO1
Isotype
Mouse IgG2b
Immunogen
Full-length SOCS3 protein. The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor.
Reactive Species
M00274 is reactive to SOCS3 in Human
Observed Molecular Weight
42 kDa
Background of SOCS3
SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M00274 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: Positive control: HeLa human cervix carcinoma cell line, reducing conditions.
Validation Images & Assay Conditions
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Western blotting analysis (reducing conditions) of whole cell lysate of HeLa human cervix carcinoma cell line.
Lane 1: immunostaining with Isotype mouse IgG2b control (PLRV219)
Lane 2: immunostaining with anti-SOCS3 (SO1)
Specific Publications For Anti-SOCS3 Purified Monoclonal Antibody (M00274)
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