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- Table of Contents
Sequestosome-1 Antibodies
AND SQSTM1 ELISA kits, Sequestosome-1 Proteins
Many biological assays use antibodies to detect Sequestosome-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sequestosome-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sequestosome-1 antibodies...
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SQSTM1 Infographic by Boster Bio
All SQSTM1 Products
Product
Figures
Specificity
Applications
Price
Anti-SQSTM1/p62 Antibody Picoband®
33 Citations 16 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # PB9444
100 μg/vial
Cat # PB9444
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA1955
100 μg/vial
Cat # PA1955
100 μg/vial
Anti-p62/SQSTM1 Rabbit Monoclonal Antibody
11 Citations 15 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00300
100 μl
Cat # M00300
100 μl
Anti-SQSTM1/p62 Antibody Picoband® (monoclonal, 3H11)
7 Citations 6 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00300-1
100 μg/vial
Cat # M00300-1
100 μg/vial
Anti-SQSTM1 / p62 Rabbit Monoclonal Antibody
4 Citations
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00300-3
100 μl/vial
Cat # M00300-3
100 μl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00300-5
20μL, 40μL, 100μL, 200μL
Cat # M00300-5
20μL, 40μL, 100μL, 200μL
SQSTM1 Overview
Facts about Sequestosome-1.
Sequestosome-1 (SQSTM1)
Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated freight and autophagosomes.
Interacts directly with both the freight to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Together with WDFY3, involved with the formation and autophagic degradation of cytoplasmic ubiquitin- containing inclusions (p62 bodies, ALIS/aggresome-like induced structures).
Gene Information
| Human | |
|---|---|
| Gene Name: | SQSTM1 |
| Uniprot: | Q13501 |
| Entrez: | 8878 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
A170; Autophagy Receptor P62; DMRV; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; FTDALS3; NADGP; ORCA; OSIL; oxidative stress induced like; p60PDB3; p62; p62B; Paget disease of bone 3; PDB3; phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Sequestosome 1; sequestosome-1; SQSTM1; Ubiquitin-binding protein p62; ZIP3
Molecular Weight
Mass (kDA):
47.687 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q35.3 |
| Sequence: | 5; NC_000005.10 (179806393..179838078) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Cytoplasm, cytosol. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Nucleus, PML body. Cytoplasm, myofibril, sarcomere. In cardiac muscle, localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic st
Diseases
- Osteitis Deformans
- Bone Diseases
- Malignant Neoplasms
- Neurodegenerative Disorders
- Neoplasms
- Dementia
- Nerve Degeneration
- Inflammation
- Alzheimer's Disease
- Liver Carcinoma
- Parkinson Disease
- Carcinoma
- Sclerosis
Interacting Proteins
- BAG3
- CDC37
- DAZAP2
- FHOD3
- GABARAP
- GABARAPL1
- GABARAPL2
- HTT
- IKBKG
- KEAP1
Pathways
- Autophagy
- Pathogenesis
- Cell Death
- Localization
- Macroautophagy
- Transport
- Bone Remodeling
- Bone Resorption
- Aging
- Cell Cycle
- Cell Proliferation
- Proteolysis
- Rna Interference
PTMs
- Ubiquitination
- Phosphorylation
- Cleavage
Research Areas
- Adaptive Immunity
- Cancer
- Chromatin Modifiers
- Chromatin Research
- DNA Methyltransferases
- Epigenetics
- Innate Immunity
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SQSTM1
bosterbio.com/bosterbio-gene-info-cards/SQSTM1
References
PMID: 8551575 by Devergne O., et al. A novel interleukin-12 p40-related protein induced by latent Epstein- Barr virus infection in B lymphocytes.
PMID: 8650207 by Joung I., et al. Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain.
16 Publications of Boster Sequestosome-1 Antibodies & ELISA Kits
- PubMed ID: 10.3390/ijms19123948, Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gen...
- PubMed ID: 10.1093/jnen/nlaa007, Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/se...
- PubMed ID: 10.1089/ars.2017.7044, Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Iso...
- PubMed ID: -, Zhiwei Liao,Suyun Li,Rong Liu,Xiaobo Feng,Yunsong Shi,Kun Wang,Shuai Li,Yukun Zh...
- PubMed ID: -, Zhang Tao,Xiaoqing Zhou,Yan Zhang,Wenfeng Pu,Yi Yang,Fuxia Wei,Qian Zhou,Lin Zha...
- PubMed ID: -, Liu, J.,Qin, X.,Ma, W.,Jia, S.,Zhang, X.,Yang, X. ... Jin, F. (2021). Corilagin ...
- PubMed ID: 32098126, Zhong W,Tang X,Liu Y,Zhou C,Liu P,Li E,Zhong P,Lv H,Zou Q,Wang M.Benzoxazole Der...
- PubMed ID: 32425551, Liu X,Feng C,Wei G,Kong W,Meng H,Du Y,Li J.Mitofusin1 Is a Major Mediator in Glu...
- PubMed ID: 32015954, Yuan H,Wang Y,Chen H,Cai X.Protective effect of flavonoids from Rosa roxburghii ...
- PubMed ID: 31900522, Song L,Yao L,Zhang L,Piao Z,Lu Y.Schizandrol A protects against Aβ1-42-induced ...
- PubMed ID: 29085598, Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduce...
- PubMed ID: 28266555, Interferon regulatory factor-1 activates autophagy to aggravate hepatic ischemia...
- PubMed ID: 27383629, Nrf2 signalling andautophagyare involved in diabetes mellitus-induced defects in...
- PubMed ID: 26228022, Dual attenuation of proteasomal and autophagic BMAL1 degradation in Clock?19/+ ...
- PubMed ID: 26120766, Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitocho...
- PubMed ID: 29052054, Song J, Hu Y, Li J, Zheng H, Wang J, Guo L, Shi H, Liu L. Arch Virol. 2018 Jan;1...
*More publications can be found for each product on its corresponding product page