Sequestosome-1 (SQSTM1)

Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated freight and autophagosomes.

Interacts directly with both the freight to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Together with WDFY3, involved with the formation and autophagic degradation of cytoplasmic ubiquitin- containing inclusions (p62 bodies, ALIS/aggresome-like induced structures).