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Toll-like receptor 8 Antibodies
AND TLR8 ELISA kits, Toll-like receptor 8 Proteins
Many biological assays use antibodies to detect Toll-like receptor 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Toll-like receptor 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Toll-like receptor 8 antibodies...
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TLR8 Infographic by Boster Bio
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TLR8 Overview
Facts about Toll-like receptor 8.
Toll-like receptor 8 (TLR8)
Key part of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to germs.
Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory reaction. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TLR8 |
| Uniprot: | Q9NR97 |
| Entrez: | 51311 |
Family
| Belongs to: |
|---|
| Toll-like receptor family |
Alternative Names
CD288 antigen; CD288; MGC119599; MGC119600; TLR8; toll-like receptor 8
Molecular Weight
Mass (kDA):
119.828 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp22.2 |
| Sequence: | X; NC_000023.11 (12906620..12923169) |
Tissue Specificity
Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Innate Immune Response
- Virus Diseases
- Inflammation
- Infective Disorder
- Malignant Neoplasms
- Neoplasms
- Autoimmune Reaction
- Autoimmune Diseases
- Hiv Infections
- Influenza
- Hepatitis
- Inflammatory Response
Pathways
- Immune Response
- Cytokine Production
- Secretion
- Pathogenesis
- Innate Immune Response
- Localization
- Cell Activation
- Inflammatory Response
- Cytokine Secretion
- Rna Interference
- Cell Proliferation
- Viral Replication
- Chemokine Production
PTMs
- Phosphorylation
- Methylation
- Phosphorothioation
- Ubiquitination
Research Areas
- Cytokine Research
- Immunology
- Innate Immunity
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TLR8
bosterbio.com/bosterbio-gene-info-cards/TLR8
References
PMID: 11022119 by Du X., et al. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution.
PMID: 11022120 by Chuang T.-H., et al. Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9.
1 Publications of Boster Toll-like receptor 8 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.cellbi.2008.04.023, Inhibition of lipopolysaccharide‐mediated rat alveolar macrophage activation i...
*More publications can be found for each product on its corresponding product page