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- Table of Contents
TRPC6 Antibodies
AND TRPC6 ELISA kits, TRPC6 Proteins
Many biological assays use antibodies to detect TRPC6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPC6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPC6 antibodies...
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TRPC6 Infographic by Boster Bio
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TRPC6 Overview
Facts about Short transient receptor potential channel 6.
Short transient receptor potential channel 6 (TRPC6)
Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.
Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRPC6 |
| Uniprot: | Q9Y210 |
| Entrez: | 7225 |
Family
| Belongs to: |
|---|
| transient receptor (TC 1.A.4) family |
Alternative Names
FLJ11098; FSGS2; short transient receptor potential channel 6; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; TRP-6; TRP6FLJ14863; TrpC6
Molecular Weight
Mass (kDA):
106.326 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q22.1 |
| Sequence: | 11; NC_000011.10 (101451470..101584007, complement) |
Tissue Specificity
Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Focal Glomerulosclerosis
- Hypertensive Disease
- Glomerulosclerosis (disorder)
- Kidney Diseases
- Segmental Glomerulosclerosis
- Pathologic Vasoconstriction
- Hypertrophy
- Proteinuria Of Undiagnosed Cause
- Nephrotic Syndrome
- Cardiac Hypertrophy
- Hypoxia
- Malignant Neoplasms
- Pulmonary Hypertension
Interacting Proteins
- MX1
Pathways
- Pathogenesis
- Vasoconstriction
- Cell Proliferation
- Store-operated Calcium Entry
- Localization
- Membrane Depolarization
- Secretion
- Cell Growth
- Rna Interference
- Glomerular Filtration
- Cell Cycle
- Angiogenesis
- Cell Migration
PTMs
- Phosphorylation
- Biotinylation
- Dephosphorylation
- Glycosylation
- Reduction
- Nitrosylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPC6
bosterbio.com/bosterbio-gene-info-cards/TRPC6
References
PMID: 9930701 by Hofmann T., et al. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.
PMID: 9925922 by D'Esposito M., et al. Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22.
3 Publications of Boster TRPC6 Antibodies & ELISA Kits
- PubMed ID: 32844288, Wang Y,Liu L,Tao H,Wen L,Qin S.TRPC6 participates in the development of blood pr...
- PubMed ID: 27472391, TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultur...
- PubMed ID: 20307499, Sun Yh, Li Yq, Feng Sl, Li Bx, Pan Zw, Xu Cq, Li Tt, Yang Bf. Biochem Biophys Re...
*More publications can be found for each product on its corresponding product page