UBA2 Antibodies

AND UBA2 ELISA kits, UBA2 Proteins

Many biological assays use antibodies to detect UBA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBA2 antibodies...

We validate the specificity of these antibodies to UBA2 by testing them on tissues known to express UBA2 positively and negatively. Browse below to find the UBA2 antibody that suites your experiment. We have 8 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UBA2 Infographic by Boster Bio

All UBA2 Products

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Specificity

Applications

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Anti-SAE2/UBA2 Antibody Picoband®

Western blot analysis of SAE2/UBA2 using anti-SAE2/UBA2 antibody (A03816-2)

Flow Cytometry analysis of A431 cells using anti-SAE2/UBA2 antibody (A03816-2)

IHC analysis of SAE2/UBA2 using anti-SAE2/UBA2 antibody (A03816-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB

$370
Cat # A03816-2
100 μg/vial

Anti-SAE2 / UBA2 Monoclonal Antibody

4 Q&As

Western blot analysis of SAE2 / UBA2 expression in A549 cell lysate

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$370
Cat # M03816
100 μl

Uba2 Colorimetric Cell-Based ELISA Kit

Western blot analysis of extracts from 293 cells

Human

ELISA

$480
Cat # EKC1584
1 kit, containing one 96-well plate and all necessary reagents

Anti-SAE2/UBA2 Antibody Picoband® (monoclonal, 5H11)

1 Q&As

Western blot analysis of UBA2 using anti-UBA2 antibody (M03816-1)

Flow Cytometry analysis of A431 cells using anti-UBA2 antibody (M03816-1)

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # M03816-1
100 μg/vial

Anti-SAE2/UBA2 Antibody Picoband® (monoclonal, 5B13)

Western blot analysis of SAE2/UBA2 using anti-SAE2/UBA2antibody (M03816-2)

IHC analysis of SAE2/UBA2 using anti-SAE2/UBA2 antibody (M03816-2)

Human, Mouse, Rat

IHC, WB

$370
Cat # M03816-2
100 μg/vial

Anti-SAE2 (S621) UBA2 Antibody

Western blot (WB) analysis of SAE2 (S621) polyclonal antibody at 1:500 dilution
Lane1:A549 whole cell lysate(40ug)
Lane2:HEK293T whole cell lysate(40ug)
Lane3:H1792 whole cell lysate(40ug)
Lane4:PC12 whole cell lysate(40ug)
Lane5:BV2 whole cell lysate(40ug)

Human

IF, IHC, WB

$405
Cat # A03816S621
100ul

Human UBA2 Recombinant Protein

SDS-PAGE

$275
Cat # PROTQ9UBT2
Starting from 10ug

UBA2 (NM_005499) Human Over-expression Lysate

Human

$628
Cat # LS010054
20 µg, 100 µg

UBA2 Overview

Facts about SUMO-activating enzyme subunit 2.

UBA2 3D structure. Source: alphafold

SUMO-activating enzyme subunit 2 (UBA2)

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4.
It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Gene Information

Human
Gene Name:	UBA2
Uniprot:	Q9UBT2
Entrez:	10054

Family

Belongs to:

ubiquitin-activating E1 family

Alternative Names

Anthracycline-associated resistance ARX; ARX; EC 6.3.2; EC 6.3.2.-; FLJ13058; HRIHFB2115; SAE2SUMO-1 activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; SUMO-activating enzyme subunit 2; UBA2, ubiquitin-activating enzyme E1 homolog; Ubiquitin-like 1-activating enzyme E1B; ubiquitin-like modifier activating enzyme 2; UBLE1B

Molecular Weight

Mass (kDA):
71.224 kDA

Genomic Context


Human

Location:	19q13.11
Sequence:	19; NC_000019.10 (34428176..34471251)

Subcellular Localizations

Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.

Diseases

Malignant Neoplasms
Acute Promyelocytic Leukemia
Leukemia
Carcinoma
Dysplasia
Neoplasms
Mammary Neoplasms
Cell Transformation, Neoplastic
Hiv Infections
Hyperplasia
Radiation Injury
Dermatomyositis
Hepatitis B

Lung Diseases
Benign Prostatic Hypertrophy
Dermatomyositis, Childhood Type
Pregnancy Complications, Infectious
Myopathy
Immunologic Deficiency Syndromes
Carcinoma In Situ

Interacting Proteins

SAE1
SUMO1
SUMO1P1
UBE2I

Pathways

Conjugation
Localization
Cell Cycle
Mitosis
Dna Repair
Protein Sumoylation
Proteolysis
Hypersensitivity
Nuclear Import
Dna Replication
Cell Death
Pathogenesis
Rna Interference

Transport
Programmed Cell Death
Nuclear Export
Sexual Reproduction
Spermatogenesis
Cytokinesis
Nuclear Transport

PTMs

Sumoylation
Ubiquitination

Cleavage
Oxidation

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBA2

References

PMID: 9920803 by Okuma T., et al. In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2.

PMID: 10217437 by Gong L., et al. Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex.

UBA2 Antibodies

AND UBA2 ELISA kits, UBA2 Proteins

UBA2 Infographic by Boster Bio

All UBA2 Products

UBA2 Overview

SUMO-activating enzyme subunit 2 (UBA2)

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Gene Information

Family

Alternative Names

Molecular Weight

Genomic Context

Subcellular Localizations

Diseases

Interacting Proteins

Pathways

PTMs

Research Areas

References

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4.
It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.