Anti-ARHGEF4 Purified Monoclonal Antibody

ARHGEF4 antibody

Boster Bio Anti-ARHGEF4 Purified Monoclonal Antibody (Catalog# M07246). Tested in Flow Cytometry, WB application(s). This antibody reacts with Human.

Product Info Summary

SKU: M07246
Size: 0.1 mg
Reactive Species: Human
Host: Mouse
Application: Flow Cytometry, WB

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Product Name

Anti-ARHGEF4 Purified Monoclonal Antibody

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SKU/Catalog Number

M07246

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-ARHGEF4 Purified Monoclonal Antibody (Catalog# M07246). Tested in Flow Cytometry, WB application(s). This antibody reacts with Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-ARHGEF4 Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M07246)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

ARHGEF-08

Isotype

Mouse IgG1

Immunogen

Recombinant fragment of human ARHGEF4 (amino acids 143-271). The mouse monoclonal antibody ARHGEF-08 recognizes human intracellular protein ARHGEF4 / ASEF1, approx. 80 kDa guanine nucleotide exchange factor specific for Rac1 and Cdc42. The epitope is located in the rough at the region of SH3 domain.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

As in case with other anti-CD170 antibodies, this antibody cross-reacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.

Reactive Species

M07246 is reactive to ARHGEF4 in Human

Applications

M07246 is guaranteed for Flow Cytometry, WB Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

79.067kDa

Background of ARHGEF4

ARHGEF4 (Rho guanine nucleotide exchange factor 4), also known as ASEF 1 (adenomatous polyposis coli –; stimulated guanine nucleotide exchange factor 1) is an approximately 80 kDa cytoplasmic protein important for growth factor-mediated regulation of cell morphology and migration. Besides N-terminal adenomatous polyposis coli (APC)-binding region (ABR) it contains Dbl homology (DH), pleckstrin homology (PH) and SH3 domains. The SH3 domain inhibits GEF activity of ARHGEF4 by intramolecular interaction with the DH domain, whereas binding of APC stimulates the GEF activity. Activated ARHGEF4 stimulates the small GTPase Cdc42, which leads to decreased cell-cell adherence and enhanced cell migration.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 1-4 μg/ml. Intracellular staining.

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For ARHGEF4 (Source: Uniprot.org, NCBI)

Gene Name

ARHGEF4

Full Name

Rho guanine nucleotide exchange factor 4

Weight

79.067kDa

Alternative Names

APC-stimulated guanine nucleotide exchange factor 1; Asef; ASEF1; ASEFAPC-stimulated guanine nucleotide exchange factor; GEF4; KIAA1112; Rho guanine nucleotide exchange factor (GEF) 4; rho guanine nucleotide exchange factor 4; STM6 ARHGEF4 ASEF, ASEF1, GEF4, SMIM39, STM6 Rho guanine nucleotide exchange factor 4 rho guanine nucleotide exchange factor 4|APC-stimulated guanine nucleotide exchange factor 1|Rho guanine nucleotide exchange factor (GEF) 4

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ARHGEF4, check out the ARHGEF4 Infographic

ARHGEF4 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ARHGEF4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M07246

0.1 mg

$305

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
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