Rho guanine nucleotide exchange factor 4 (ARHGEF4)

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity.

The APC-ARHGEF4 complex appears to be involved in cell migration in addition to in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells.