Product Info Summary
SKU: | A05491S383 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IF, IHC |
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Product info
Product Name
Anti-Chemokine Receptor D6 (S383) ACKR2 Antibody
View all CC Chemokine Receptor D6 Antibodies
SKU/Catalog Number
A05491S383
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Chemokine Receptor D6 (S383) ACKR2 Antibody catalog # A05491S383. Tested in IHC,IF applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Chemokine Receptor D6 (S383) ACKR2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05491S383)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Chemokine Receptor D6
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A05491S383 is reactive to ACKR2 in Human, Mouse, Rat
Applications
A05491S383 is guaranteed for IF, IHC Boster Guarantee
Observed Molecular Weight
111 kDa
Calculated molecular weight
43.443kDa
Background of CC Chemokine Receptor D6
Isoform GANP:Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP:Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.
Nobuo Sakaguchi, J. Immunol., Apr 2005; 174: 4485 - 4494.
Kazuhiko Kuwahara, Blood, Apr 2000; 95: 2321 - 2328.
Y Kono, K Maeda, Genes Cells, Aug 2002; 7: 821 - 834.
Kazuhiko Kuwahara, PNAS, Aug 2001; 98: 10279.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC: 1:50-1:200
IF: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunohistochemistry validation of ACKR2 using Anti-Chemokine Receptor D6 (S383) ACKR2 Antibody (A05491S383).
Immunohistochemistry (IHC) analyzes of Chemokine Receptor D6 (S383) pAb in paraffin-embedded human lung carcinoma tissue at 1:50.showing cell membrane staining. Negative control (the right)Using PBS instead of primary antibodyClick image to see more details
Figure 2. Immunohistochemistry validation of ACKR2 using Anti-Chemokine Receptor D6 (S383) ACKR2 Antibody (A05491S383).
Immunohistochemistry (IHC) analyzes of Chemokine Receptor D6 (S383) pAb in paraffin-embedded human liver carcinoma tissue at 1:50.showing cell membrane staining. Negative control (the right)Using PBS instead of primary antibodyProtein Target Info & Infographic
Gene/Protein Information For ACKR2 (Source: Uniprot.org, NCBI)
Gene Name
ACKR2
Full Name
Atypical chemokine receptor 2
Weight
43.443kDa
Superfamily
G-protein coupled receptor 1 family
Alternative Names
ACKR2; C-C chemokine receptor D6; CCBP2; CCR10CCR9D6CC-chemokine-binding receptor JAB61; chemokine (C-C) receptor 9; chemokine binding protein 2; Chemokine receptor CCR-10; Chemokine receptor CCR-9; chemokine receptor D6; chemokine-binding protein 2; Chemokine-binding protein D6; CMKBR9; CMKBR9chemokine (C-C motif) receptor 9; D6; hD6; MGC126678; MGC138250 ACKR2 CCBP2, CCR10, CCR9, CMKBR9, D6, hD6 atypical chemokine receptor 2 atypical chemokine receptor 2|C-C chemokine receptor D6|CC-chemokine-binding receptor JAB61|chemokine (C-C motif) receptor 9|chemokine (C-C) receptor 9|chemokine receptor CCR-10|chemokine receptor CCR-9|chemokine receptor D6|chemokine-binding protein 2|chemokine-binding protein D6
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ACKR2, check out the ACKR2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ACKR2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Chemokine Receptor D6 (S383) ACKR2 Antibody (A05491S383)
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