Anti-Decorin/DCN Antibody

DCN antibody

Boster Bio Anti-Decorin/DCN Antibody catalog # PA1314. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 3 publication(s).

Product Info Summary

SKU: PA1314
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: WB

Product Name

Anti-Decorin/DCN Antibody

View all DCN Antibodies

SKU/Catalog Number

PA1314

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Decorin/DCN Antibody catalog # PA1314. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Decorin/DCN Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1314)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Decorin, identical to the related mouse sequence, and different from the related rat sequence by three amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1314 is reactive to DCN in Human, Mouse, Rat

Applications

PA1314 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

40-50 kDa, 80-140 kDa

Calculated molecular weight

39.747kDa

Background of DCN

Decorin is a proteoglycan on average 90-140 kilodaltons (kD) in size. The human decorin gene spans more than 38 kb and contains 8 exons and very large introns, 2 of which are 5.4 and more than 13.2 kb. And the human decorin gene is mapped to 12q21.3. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are though to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. And it also may play a role in epithelial/mesenchymal interactions during organ development and shaping. Decorin has been shown to have anti-tumorigenic properties in an experimental murine tumor model and is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for the decorin gene. Mutations in the decorin gene are associated with congenital stromal corneal dystrophy.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Innovating Scientists Reward

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Validation Images & Assay Conditions

Gene/Protein Information For DCN (Source: Uniprot.org, NCBI)

Gene Name

DCN

Full Name

Decorin

Weight

39.747kDa

Superfamily

small leucine-rich proteoglycan (SLRP) family

Alternative Names

Bone proteoglycan II; CSCD; DCN; decorin proteoglycan; Decorin; dermatan sulphate proteoglycans II; DSPG2; PG40; PGII; PG-II; PGS2; PG-S2; proteoglycan core protein; SLRR1B; SLRR1BPGS2; small leucine-rich protein 1B DCN CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B decorin decorin|bone proteoglycan II|dermatan sulphate proteoglycans II|proteoglycan core protein|small leucine-rich protein 1B

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on DCN, check out the DCN Infographic

DCN infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for DCN: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PA1314 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

An Animal Model of Modic Changes by Embedding Autogenous Nucleus Pulposus inside Subchondral Bone of Lumbar Vertebrae

Lai J, Chen F, Chen J, Ruan G, He M, Chen C, Tang J, Wang DW. Sci Rep. 2017 Mar 14;7:44473. doi: 10.1038/srep44473. Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling

Huang Gf, Zou J, Shi J, Zhang Dy, Pen Hf, Zhang Q, Gao Y, Wang By. Evid Based Complement Alternat Med. 2014;2014:731395. Doi: 10.1155/2014/731395. Epub 2014 May 27. The Effect Of Electroacupuncture On The Extracellular Matrix Synthesis And Degrada...

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7 Customer Q&As for Anti-Decorin/DCN Antibody

Question

We appreciate helping with my inquiry over the phone. Here are the WB image, lot number and protocol we used for lung using anti-Decorin/DCN antibody PA1314. Let me know if you need anything else.

Verified Customer

Verified customer

Asked: 2019-12-20

Answer

Thank you for the data. You have provided everything we needed. Our lab team are working to resolve your inquiry as quickly as possible, and we appreciate your patience and understanding! Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2019-12-20

Question

I have attached the WB image, lot number and protocol we used for lung using anti-Decorin/DCN antibody PA1314. Please let me know if you require anything else.

Verified Customer

Verified customer

Asked: 2019-12-06

Answer

Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2019-12-06

Question

Is a blocking peptide available for product anti-Decorin/DCN antibody (PA1314)?

Verified Customer

Verified customer

Asked: 2019-01-16

Answer

We do provide the blocking peptide for product anti-Decorin/DCN antibody (PA1314). If you would like to place an order for it please contact [email protected] and make a special request.

Boster Scientific Support

Answered: 2019-01-16

Question

I see that the anti-Decorin/DCN antibody PA1314 works with WB, what is the protocol used to produce the result images on the product page?

Verified Customer

Verified customer

Asked: 2018-09-17

Answer

You can find protocols for WB on the "support/technical resources" section of our navigation menu. If you have any further questions, please send an email to [email protected]

Boster Scientific Support

Answered: 2018-09-17

Question

Will anti-Decorin/DCN antibody PA1314 work on horse WB with decidua?

Verified Customer

Verified customer

Asked: 2018-05-29

Answer

Our lab technicians have not validated anti-Decorin/DCN antibody PA1314 on horse. You can run a BLAST between horse and the immunogen sequence of anti-Decorin/DCN antibody PA1314 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated horse samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in horse decidua in WB, you can get your next antibody for free.

Boster Scientific Support

Answered: 2018-05-29

Question

I was wanting to use your anti-Decorin/DCN antibody for WB for mouse lung on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for mouse lung identification?

C. Krishna

Verified customer

Asked: 2016-04-21

Answer

It shows on the product datasheet, PA1314 anti-Decorin/DCN antibody has been validated for WB on human, mouse, rat tissues. We have an innovator award program that if you test this antibody and show it works in mouse lung in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2016-04-21

Question

Is this PA1314 anti-Decorin/DCN antibody reactive to the isotypes of DCN?

T. Bhatt

Verified customer

Asked: 2013-03-26

Answer

The immunogen of PA1314 anti-Decorin/DCN antibody is A synthetic peptide corresponding to a sequence at the C-terminus of human Decorin(343-359aa TFRCVYVRSAIQLGNYK), identical to the related mouse sequence, and different from the related rat sequence by three amino acids. Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?

Boster Scientific Support

Answered: 2013-03-26

Order DetailsPrice
PA1314

100μg

$370
PA1314-10ug

10μg sample (liquid)

$99
PA1314-Biotin

100 μg Biotin conjugated

$570
PA1314-Cy3

100 μg Cy3 conjugated

$570
PA1314-Dylight488

100 μg Dylight488 conjugated

$570
PA1314-Dylight550

100 μg Dylight550 conjugated

$570
PA1314-Dylight594

100 μg Dylight594 conjugated

$570
PA1314-FITC

100 μg FITC conjugated

$570
PA1314-HRP

100 μg HRP conjugated

$570
PA1314-APC

100 μg APC conjugated

$670
PA1314-PE

100 μg PE conjugated

$670
PA1314-carrier-free

Carrier Free

$370

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
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