Anti-Dopamine Receptor D1/DRD1 Antibody
Rabbit IgG polyclonal antibody for D(1A) dopamine receptor(DRD1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Anti-Dopamine Receptor D1/DRD1 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Dopamine Receptor D1/DRD1 Antibody
See all Dopamine D1R/DRD1 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for DOPAMINE RECEPTOR D1/DRD1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. DOPAMINE RECEPTOR D1/DRD1 information: Molecular Weight: 49293 MW; Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14; Tissue Specificity: Detected in caudate, nucleus accumbens and in the olfactory tubercle.|
|Cite This Product||Anti-Dopamine Receptor D1/DRD1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1571)|
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|Anti-Dopamine Receptor D1/DRD1 Antibody may replace the following items: sc 14001|sc 1434|sc 31478|sc 31479|sc 33660.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human DRD1 (221-242aa AQKQIRRIAALERAAVHAKNCQ), different from the related rat and mouse sequences by one amino acid.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For DRD1 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||1812|
|Species Of This Entry||Human|
|Protein Name||D(1A) dopamine receptor|
|Superfamily||G-protein coupled receptor 1 family|
|Alternative Names||Dopamine D1R/DRD1|D(1A) dopamine receptor; D1DR; DADR; Dopamine D1 R; Dopamine D1 receptor; Dopamine D1R; dopamine receptor D1; DRD1; DRD1A|
|Post Tranlational Modifications||Methylation; Phosphorylation; Demethylation|
|Subcellular Localization||Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.|
|Gene Location||5q35.2, on Chromasome 5, gene sequence: NC_000005.10 (175440036..175444182, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For DRD1 (Source: Uniprot.org, NCBI)
|Protein Function||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|
|Tissue Specificity||Detected in caudate, nucleus accumbens and in the olfactory tubercle.|
|Research Areas||GPCR; Neuroscience; Neurotransmission|
|Related Diseases||Schizophrenia; Bipolar Disorder; Attention Deficit Hyperactivity Disorder; Dysequilibrium Syndrome; Mental Disorders; Psychotic Disorders; Depressive Disorder; Nervousness; Variable Number Tandem Repeat; Hypertensive Disease; Mood Disorders; Parkinson Disease; Alzheimer's Disease; Substance-related Disorders; Malnutrition; Gilles De La Tourette Syndrome; Dyskinetic Syndrome|
|Related Pathways||Methylation; Dna Methylation; Pathogenesis; Rna-directed Dna Methylation; Gene Silencing; Excretion; Localization; Cognition; Secretion; Renal Sodium Excretion; Chromatin Modification; Chromatin Remodeling; Glomerular Filtration; Regulation Of Dna Methylation; Maternal Behavior; Rna Interference; Cell Migration; Swimming; Interphase; Histone Methylation|
|Background||Dopamine receptor D1, also known as DRD1, is a human gene. It is the most highly expressed DA receptor subtype among the DA receptor family. Receptors for dopamine have been classified into two functional types, D1 and D2. They belong to the family of receptors acting through G(or guanine nucleotide-binding) proteins. D2 receptors inhibit adenylyl cyclase, but D1 receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases. Dopamine D1 and D2 receptors are targets of drug therapy in many psychomotor disorders, including Parkinson's disease and schizophrenia, and may also have a role in drug addiction and alcoholism. D1 receptors regulate neuron growth and differentiation, influence behaviour and modify dopamine D2 receptor-mediated events. And the presence of a D1 receptor gene restriction fragment length polymorphism will be helpful for future disease linkage studies. DRD1 also regulates the neurochemical architecture of the striatum and is critical for the normal expression of motor activity.|
|Scientific References||PMID: 2144334 by Dearry A., et al. Molecular cloning and expression of the gene for a human D1 dopamine receptor.|
PMID: 2168520 by Zhou Q.-Y., et al. Cloning and expression of human and rat D1 dopamine receptors.
Our Boster Quality Guarantee for Anti-Dopamine Receptor D1/DRD1 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Rat Testis Tissue Lysate
Lane 2: Rat Brain Tissue Lysate
Lane 3: U87 Cell Lysate
Lane 4: HELA Cell Lysate
IHC(P): Rat Brain Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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