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Product Info Summary
| SKU: | A01688 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Endoribonuclease ZC3H12A ZC3H12A Antibody
SKU/Catalog Number
A01688
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Endoribonuclease ZC3H12A ZC3H12A Antibody (Catalog # A01688). Tested in ELISA, WB applications. This antibody reacts with Human.
Storage & Handling
ZC3H12A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Endoribonuclease ZC3H12A ZC3H12A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01688)
Host
Rabbit
Contents
ZC3H12A Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ZC3H12A antibody was raised against a 17 amino acid synthetic peptide near the center of human ZC3H12A. The immunogen is located within amino acids 330 - 380 of ZC3H12A.
Cross-reactivity
This ZC3H12A antibody is predicted to have no cross-reactivity to other members of the ZC3H12 protein family.
Reactive Species
A01688 is reactive to ZC3H12A in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
65.7 kDa
Background of ZC3H12A
ZC3H12A, also known as MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. ZC3H12A has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPgamma, demonstrating the complex roles ZC3H12A plays.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01688 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ZC3H12A antibody can be used for detection of ZC3H12A by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ZC3H12A in K562 cell lysate with ZC3H12A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Specific Publications For Anti-Endoribonuclease ZC3H12A ZC3H12A Antibody (A01688)
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