Rabbit IgG polyclonal antibody for Haptoglobin(HP) detection. Tested with WB, IHC-P in Human. Cited in 1 publication(s).
Anti-Haptoglobin/HP Antibody Info At A Glance
|Product Name||Anti-Haptoglobin/HP Antibody
See all Haptoglobin primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for HAPTOGLOBIN/HP detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. HAPTOGLOBIN/HP information: Molecular Weight: 45205 MW; Subcellular Localization: Secreted; Tissue Specificity: Expressed by the liver and secreted in plasma.|
|Cite This Product||Anti-Haptoglobin/HP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1599)|
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|Anti-Haptoglobin/HP Antibody may replace the following items: sc 134464|sc 134465|sc 134466|sc 19634|sc 22915|sc 22916|sc 25871|sc 271915|sc 28434|sc 292875|sc 32931|sc 365396|sc 374208|sc 376893|sc 390796|sc 390962|sc 50344|sc 514057|sc 51625|sc 55957 R|sc 55959 R|sc 59143|sc 65270|sc 68667|sc 68668|sc 69782|sc 69783|sc 69891|sc 69892.|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human Haptoglobin(294-309aa DHLKYVMLPVADQDQC).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For HP (Source: Uniprot.org, NCBI)
|NCBI Gene Id||3240|
|Species Of This Entry||Human|
|Superfamily||peptidase S1 family|
|Alternative Names||Haptoglobin|binding peptide; BP; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; Haptoglobin; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; HP; HP-1; hp2-alpha; HP2ALPHA2; HPA1S; MGC111141; zonulin|
|Post Tranlational Modifications||Oxidation; Phosphorylation; Cleavage; Glycosylation; Methylation; Reduction; Nitration; Hydroxylation; Biotinylation; Acetylation; Acylation; Amidation; Carboxylation; Dephosphorylation; Deamination; Amination; Deacetylation; Deglycosylation; Decarboxylation; Bromination|
|Gene Location||16q22.2, on Chromasome 16, gene sequence: NC_000016.10 (72054505..72061056)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For HP (Source: Uniprot.org, NCBI)
|Protein Function||As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.|
|Tissue Specificity||Expressed by the liver and secreted in plasma.|
|Interacting Proteins||APOA1; APOE|
|Related Diseases||Helicobacter Infections; Gastritis; Malignant Neoplasms; Ulcer; Neoplasms; Inflammation; Helicobacter Pylori Infection; Peptic Ulcer; Duodenal Ulcer; Malignant Neoplasm Of Stomach; Stomach Neoplasms; Carcinoma; Diabetes Mellitus; Gastric Ulcer; Dyspepsia; Pneumonia; Pain; Hyperplastic Polyp; Infective Disorder|
|Related Pathways||Pathogenesis; Secretion; Excretion; Hypersensitivity; Transport; Localization; Immune Response; Acid Secretion; Cell Proliferation; Inflammatory Response; Lactation; Virulence; Aging; Gastric Acid Secretion; Cell Death; Glomerular Filtration; Protein Folding; Translation; Regeneration; Angiogenesis|
|Background||Haptoglobin(HP), is a protein that in humans is encoded by the HP gene. Haptoglobin, a plasma glycoprotein that binds free hemoglobin, has a tetrameric structure of 2 alpha and 2 beta polypeptides that are covalently associated by disulfide bonds. Haptoglobin is homologous to serine proteases of the chymotrypsinogen family. In the chimpanzee, there are 3 genes in the haptoglobin family(haptoglobin, HP; haptoglobin-related, HPR; and haptoglobin-primate, HPP), whereas only 2 genes exist in humans(HP and HPR). There are similarities between the primary structures of the alpha chain and of light chains of gamma globulins. The alpha haptoglobin locus is on the long arm of chromosome 16, where its exact cytogenetic location is 16q22.2. A major function of haptoglobin is to bind hemoglobin(Hb) to form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage. Haptoglobin is an unusual secretory protein in that it is proteolytically processed in the endoplasmic reticulum and not in the Golgi. The human haptoglobin HP*2 allele contains a 1.7-kb intragenic duplication that arose after a unique nonhomologous recombination between the prototype HP*1 alleles.|
|Scientific References||PMID: 6688992 by van der Straten A., et al. Molecular cloning of human haptoglobin cDNA: evidence for a single mRNA coding for alpha 2 and beta chains.|
PMID: 6310599 by Yang F., et al. Identification and characterization of human haptoglobin cDNA.
Our Boster Quality Guarantee for Anti-Haptoglobin/HP Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
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