Anti-Hu CD88 Purified C5AR1 Monoclonal Antibody

Product Name

Anti-Hu CD88 Purified C5AR1 Monoclonal Antibody

View all Complement Component C5aR1 Antibodies

SKU/Catalog Number

M01898

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Hu CD88 Purified C5AR1 Monoclonal Antibody (Catalog# M01898). Tested in Flow Cytometry, IP, WB, IHC-P application(s). This antibody reacts with Rabbit, Ferret, Cow, Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Hu CD88 Purified C5AR1 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01898)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

S5/1

Isotype

Mouse IgG2a kappa

Immunogen

Recombinant N-terminal peptide (Asp15-Asp27) of human C5aR. The mouse monoclonal antibody S5/1 recognizes an extracellular epitope of CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

This antibody does not cross-react with Thy-1.1 alloantigen.

Reactive Species

M01898 is reactive to C5AR1 in Cow, Ferret, Human, Rabbit

Applications

M01898 is guaranteed for Flow Cytometry, IP, IHC-P, WB Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

39.336kDa

Background of Complement Component C5aR1

CD88 / C5aR is a G protein-coupled seven membrane-spanning protein serving as a receptor for C5a component of the complement cascade, and is expressed mainly by monocytes, macrophages, neutrophils, eosinophils, and mast cells, but also e.g. by hepatocytes, glial cells, vascular endothelial cells, or cardiomyocytes. The binding of C5a to CD88 is associated with inflammatory response, including superoxide anion production, chemotaxis, and increased production of acute phase proteins. Expression of CD88 on synovial mast cells and their C5a-mediated degranulation plays a role in pathogenesis of rheumatoid arthritis.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 3-12 μg/ml.

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For C5AR1 (Source: Uniprot.org, NCBI)

Alternative Names

C5a anaphylatoxin chemotactic receptor; C5A; C5aR; C5a-R; C5AR1; C5ARC5a anaphylatoxin receptor; C5R1C5a ligand; CD88 antigen; CD88; complement component 5 receptor 1 (C5a ligand); complement component 5 receptor 1; complement component 5a receptor 1; Complement Component C5a R1; Complement Component C5aR1 C5AR1 C5A, C5AR, C5R1, CD88 complement C5a receptor 1 C5a anaphylatoxin chemotactic receptor 1|C5a anaphylatoxin receptor|C5a ligand|C5a-R|complement component 5a receptor 1

For more info on C5AR1, check out the C5AR1 Infographic

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In this infographic, you will see the following information for C5AR1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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