Anti-Keratin-pan KRT2 Antibody

Cytokeratin 2 antibody

Boster Bio Anti-Keratin-pan KRT2 Antibody catalog # A05667. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 1 publication(s).

Product Info Summary

SKU: A05667
Size: 100μl
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-Keratin-pan KRT2 Antibody

View all Cytokeratin 2 Antibodies

SKU/Catalog Number

A05667

Size

100μl

Form

Liquid

Description

Boster Bio Anti-Keratin-pan KRT2 Antibody catalog # A05667. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Keratin-pan KRT2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05667)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

1E3

Isotype

IgG

Immunogen

Synthesized peptide derived from human Keratin-pan around the non-acetylation site of K185.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A05667 is reactive to KRT2 in Human, Mouse, Rat

Applications

A05667 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

65.433kDa

Background of Cytokeratin 2

ROC2 also known as RING-box protein 2, Rbx2, RING finger protein 7, Regulator of cullins 2, CKII beta-binding protein 1, and CKBBP1, is a probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC2 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. ROC2 may play a role in protecting cells from apoptosis induced by redox agents. ROC2 has a cytoplasmic and nuclear localization and is expressed in heart, liver, skeletal muscle and pancreas tissues, and at very low levels in brain, placenta and lung. 1,10-phenanthroline induces ROC2 expression. The RING-type zinc finger domain is essential for ubiquitin ligase activity. Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000
IHC-P, 1:100-1:300

Validation Images & Assay Conditions

Gene/Protein Information For KRT2 (Source: Uniprot.org, NCBI)

Gene Name

KRT2

Full Name

Keratin, type II cytoskeletal 2 epidermal

Weight

65.433kDa

Superfamily

intermediate filament family

Alternative Names

CK-2e; cytokeratin-2e; epidermal ichthyosis bullosa of Siemens; Epithelial keratin-2e; K2e; keratin 2; keratin 2A (epidermal ichthyosis bullosa of Siemens); keratin, type II cytoskeletal 2 epidermal; Keratin-2 epidermis; keratin-2e; KRT2AMGC116967; KRT2EMGC116968; KRTE; Type-II keratin Kb2 KRT2 CK-2e, K2eA, KRT2E, KRTE, KRT2 keratin 2 keratin, type II cytoskeletal 2 epidermal|cytokeratin-2e|epithelial keratin-2e|keratin 2, type II|keratin-2 epidermis|keratin-2e|type-II keratin Kb2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on KRT2, check out the KRT2 Infographic

KRT2 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for KRT2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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A05667 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Ovalbumin enhances YKL-40, IL-5, GM-CSF, and eotaxin expression simultaneously in primarily cultured mouse tracheal epithelial cells

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Order DetailsPrice
A05667

100uL

$399

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