radio
SKU MA1079
Size 100μg/vial
Reactivity Chicken, Human, Mouse, Rabbit, Rat, Snake
Clonality Monoclonal
Clone Number CH-19
Host Mouse
Ig Isotype Mouse IgG1
Applications IHC, WB

Overview

Product Name Anti-Pan-Cadherin Antibody (Monoclonal, CH-19)
SKU/Catalog Number MA1079
Storage & Handling At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.
Size 100μg/vial
Description Mouse IgG monoclonal antibody for Pan-Cadherin, cadherin 1, type 1, E-cadherin (epithelial); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental) (CDH1; CDH2; CDH3 ) detection. Tested with WB, IHC-P in Human;mouse;rat;rabbit;chicken;snake. No cross reactivity with other proteins.
Cite This Product Anti-Pan-Cadherin Antibody (Monoclonal, CH-19) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1079)
Host Mouse
Immunogen Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue(24 amino acids) coupled to KLH.
Reactivity Chicken, Human, Mouse, Rabbit, Rat, Snake

Assay Details

Assay Dilutions Overview

Immunohistochemistry(Paraffin-embedded Section), 2-4μg/ml, Human, mouse, rat, rabbit, chicken, snake., By Heat
Western blot, 1-2μg/ml, Human, mouse, rat, rabbit, chicken, snake.

Boster's Secondary Antibodies And IHC, WB Kits

The following reagents are used to generate the images below.

Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P).

Target Info

Protein Target Info (Source: Uniprot.org)

Uniprot Id F1LMI3
Gene Name Cdh3
Protein Name cadherin 1, type 1, E-cadherin(epithelial); cadherin 2, type 1, N-cadherin(neuronal); cadherin 3, type 1, P-cadherin(placental)
Tissue Specificity CDH1: Non-neural epithelial tissues.
Alternative Names Cadherin 3, type 1, P-cadherin (Placental) ;Protein Cdh3 ;Cdh3 ;rCG_51631 ;
Subcellular Localization CDH1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome. Golgi apparatus, trans-Golginetwork. Note: Colocalizes with DLGAP5 at sites of cell-cellcontact in intestinal epithelial cells. Anchored to actinmicrofilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calciuminflux, results in translocation from sites of cell-cell contactto the cytoplasm. Colocalizes with RAB11A endosomes during itstransport from the Golgi apparatus to the plasma membrane.|Cdh1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome Golgi apparatus,trans-Golgi network Note: Colocalizes with DLGAP5 atsites of cell-cell contact in intestinal epithelial cells.Anchored to actin microfilaments through association with alpha-,beta- and gamma-catenin. Sequential proteolysis induced byapoptosis or calcium influx, results in translocation from sitesof cell-cell contact to the cytoplasm. Colocalizes with RAB11Aendosomes during its transport from the Golgi apparatus to theplasma membrane (By similarity). |Cdh1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome Golgi apparatus,trans-Golgi network Note: Colocalizes with DLGAP5 atsites of cell-cell contact in intestinal epithelial cells.Anchored to actin microfilaments through association with alpha-,beta- and gamma-catenin. Sequential proteolysis induced byapoptosis or calcium influx, results in translocation from sitesof cell-cell contact to the cytoplasm. Colocalizes with RAB11Aendosomes during its transport from the Golgi apparatus to theplasma membrane (By similarity). |CDH2: Cell membrane; Single-pass type I membraneprotein.|Cdh2: Cell membrane; Single-pass type I membraneprotein.|Cdh2: Cell membrane |CDH3: Cell membrane; Single-pass type I membraneprotein.|Cdh3: Cell membrane; Single-pass type I membraneprotein.
Molecular Weight 90415 MW

*if product is indicated to react with multiple species, protein info is based on the human gene.

Ontology

Protein Function Cadherins are calcium-dependent cell adhesion proteins. .
Background Cadherins are calcium-dependent cell-cell adhesion molecules that mediate cell-cell binding in a homophilic manner. They play an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Cadherin expression is regulated spatially as well as temporally. Cadherins are though to play an important role in development and maintenance of tissues through selective cell-cell adhesion activity and may be involved also in the invasion and metastasis of malignant tumors. Cadherin regulates dendritic spine morphogenesis. A cadherin gene cluster is mapped to a region of chromosome 5 subject to frequent allelic loss in carcinoma.

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Promotion:

Buy primary get secondary antibody for free.
Option Price
30ug sample size $99
100ug $280
100ug+Free HRP Secondary BA1050 $280
100ug+Free Biotin Secondary BA1001 $280
Ships in 5-7 business days.

Troubleshooting

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Publications

Qiu J, Zhang C, Lv Y, Zhang Y, Zhu C, Wang X, Yao W. Neurochem Int. 2013 Aug;63(2):87-92. Doi: 10.1016/J.Neuint.2013.05.009. Epub 2013 May 28. Cdh1 Inhibits Reactive Astrocyte Proliferation After Oxygen-Glucose Deprivation And Reperfusion.

Customer Q&As

Q: Is your western blot protocol provided from the website applicable for all your antibodies? Keyword: applications, WB
A: The protocol is applicable for all our antibodies in WB, the NC Membrane(0.45μm or 0.22μm) and transfer time(70 mins or 50 mins) depends on the protein molecular weight, details can be found in included protocol.
Q: Can I conjugate markers to this antibody? Can I link custom conjugates to this antibody? Keyword: conjugation
A: The antibody is stored with BSA and cannot be conjugated with markers. Carrier free antibodies are available upon request. Please contact support@bosterbio.com
Q: Can you provide monoclonal antibodies carrier free?
A: We cannot.
Q: What are some alternative names that could be used to describe this product?
A: Some common names include but are not limited to n-cadherin antibody, cdh3 antibody, p-cadherin antibody