Anti-Prealbumin/TTR Antibody Picoband™

Transthyretin/Prealbumin antibody

Boster Bio Anti-Prealbumin/TTR Antibody Picoband™ catalog # PB9749. Tested in ELISA, IHC, WB applications. This antibody reacts with Human. Cited in 1 publication(s).

Product Info Summary

SKU: PB9749
Size: 100 μg/vial
Reactive Species: Human
Host: Rabbit
Application: ELISA, IHC, WB

Product Name

Anti-Prealbumin/TTR Antibody Picoband™

View all Transthyretin/Prealbumin Antibodies

SKU/Catalog Number

PB9749

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Prealbumin/TTR Antibody Picoband™ catalog # PB9749. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Prealbumin/TTR Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9749)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human Prealbumin recombinant protein (Position: G21-E147). Human Prealbumin shares 81% and 83.3% amino acid (aa) sequence identity with mouse and rat Prealbumin, respectively.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

PB9749 is reactive to TTR in Human

Applications

PB9749 is guaranteed for ELISA, IHC, WB Boster Guarantee

Observed Molecular Weight

14 kDa

Calculated molecular weight

15.887kDa

Background of Transthyretin/Prealbumin

Transthyretin (TTR) is also known as prealbumin. It is mapped to chromosome region 18q11.2-q12.1. This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Innovating Scientists Reward

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
ELISA(Cap), 1-5 μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For TTR (Source: Uniprot.org, NCBI)

Gene Name

TTR

Full Name

Transthyretin

Weight

15.887kDa

Superfamily

transthyretin family

Alternative Names

ATTR; HsT2651; PALB; PALBTBPA; Prealbumin; prealbumin, amyloidosis type I; TBPA; thyroxine-binding prealbumin; Transthyretin; TTR TTR ATTR, CTS, CTS1, HEL111, HsT2651, PALB, TBPA, TTN transthyretin transthyretin|epididymis luminal protein 111|prealbumin, amyloidosis type I|thyroxine-binding prealbumin

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on TTR, check out the TTR Infographic

TTR infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for TTR: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PB9749 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Expression of renal cell markers and detection of 3p loss links endolymphatic sac tumor to renal cell carcinoma and warrants careful evaluation to avoid %u2026

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5 Customer Q&As for Anti-Prealbumin/TTR Antibody Picoband™

Question

My question regards using your anti-Prealbumin/TTR antibody for retinoid metabolic process studies. Has this antibody been tested with western blotting on lung cancer tissue? We would like to see some validation images before ordering.

Verified Customer

Verified customer

Asked: 2019-10-10

Answer

We appreciate your inquiry. This PB9749 anti-Prealbumin/TTR antibody is validated on lung cancer tissue. It is guaranteed to work for IHC, WB in human. Our Boster guarantee will cover your intended experiment even if the sample type has not been be directly tested.

Boster Scientific Support

Answered: 2019-10-10

Question

We ordered your anti-Prealbumin/TTR antibody for WB on liver in the past. I am using human, and We are going to use the antibody for IHC next. I am looking for examining liver as well as retina in our next experiment. Could you please give me some suggestion on which antibody would work the best for IHC?

G. Miller

Verified customer

Asked: 2019-10-04

Answer

I looked at the website and datasheets of our anti-Prealbumin/TTR antibody and it appears that PB9749 has been tested on human in both WB and IHC. Thus PB9749 should work for your application. Our Boster satisfaction guarantee will cover this product for IHC in human even if the specific tissue type has not been validated. We do have a comprehensive range of products for IHC detection and you can check out our website bosterbio.com to find out more information about them.

Boster Scientific Support

Answered: 2019-10-04

Question

My team were well pleased with the WB result of your anti-Prealbumin/TTR antibody. However we have observed positive staining in brain secreted. cytoplasm. using this antibody. Is that expected? Could you tell me where is TTR supposed to be expressed?

Verified Customer

Verified customer

Asked: 2019-08-09

Answer

From literature, brain does express TTR. Generally TTR expresses in secreted. cytoplasm. Regarding which tissues have TTR expression, here are a few articles citing expression in various tissues:
Brain, Cajal-Retzius cell, and Fetal brain cortex, Pubmed ID: 1979335
Cerebrospinal fluid, Pubmed ID: 18221012
Corpus callosum, Pubmed ID: 14702039
Liver, Pubmed ID: 1666289, 2015890, 3022108, 6093805, 15489334, 24275569
Plasma, Pubmed ID: 14760718, 16335952
Platelet, Pubmed ID: 12665801
Retina, Pubmed ID: 10328977

Boster Scientific Support

Answered: 2019-08-09

Question

We have observed staining in human cajal-retzius cell fetal brain cortex. What should we do? Is anti-Prealbumin/TTR antibody supposed to stain cajal-retzius cell fetal brain cortex positively?

Verified Customer

Verified customer

Asked: 2019-07-04

Answer

From what I have seen in literature cajal-retzius cell fetal brain cortex does express TTR. From what I have seen in Uniprot.org, TTR is expressed in pigmented layer of retina, liver, retina, corpus callosum, platelet, brain, cajal-retzius cell fetal brain cortex, plasma, cerebrospinal fluid, among other tissues. Regarding which tissues have TTR expression, here are a few articles citing expression in various tissues:
Brain, Cajal-Retzius cell, and Fetal brain cortex, Pubmed ID: 1979335
Cerebrospinal fluid, Pubmed ID: 18221012
Corpus callosum, Pubmed ID: 14702039
Liver, Pubmed ID: 1666289, 2015890, 3022108, 6093805, 15489334, 24275569
Plasma, Pubmed ID: 14760718, 16335952
Platelet, Pubmed ID: 12665801
Retina, Pubmed ID: 10328977

Boster Scientific Support

Answered: 2019-07-04

Question

We are currently using anti-Prealbumin/TTR antibody PB9749 for human tissue, and we are satisfied with the WB results. The species of reactivity given in the datasheet says human. Is it likely that the antibody can work on pig tissues as well?

T. Evans

Verified customer

Asked: 2018-01-08

Answer

The anti-Prealbumin/TTR antibody (PB9749) has not been tested for cross reactivity specifically with pig tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in pig you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2018-01-08

Order DetailsPrice
PB9749

100μg

$370
PB9749-10ug

10μg sample (liquid)

$99
PB9749-Biotin

100 μg Biotin conjugated

$570
PB9749-Cy3

100 μg Cy3 conjugated

$570
PB9749-Dylight488

100 μg Dylight488 conjugated

$570
PB9749-Dylight550

100 μg Dylight550 conjugated

$570
PB9749-Dylight594

100 μg Dylight594 conjugated

$570
PB9749-FITC

100 μg FITC conjugated

$570
PB9749-HRP

100 μg HRP conjugated

$570
PB9749-APC

100 μg APC conjugated

$670
PB9749-PE

100 μg PE conjugated

$670
PB9749-carrier-free

Carrier Free

$370

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