Anti-TGF alpha/TGFA Antibody
Rabbit IgG polyclonal antibody for Protransforming growth factor alpha(TGFA) detection. Tested with WB in Human. Cited in 3 publication(s).
Anti-TGF alpha/TGFA Antibody Info At A Glance
|Product Name||Anti-TGF alpha/TGFA Antibody
See all TGF-alpha primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for TGF ALPHA/TGFA detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. TGF ALPHA/TGFA information: Molecular Weight: 17006 MW; Subcellular Localization: Transforming growth factor alpha: Secreted, extracellular space; Tissue Specificity: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.|
|Cite This Product||Anti-TGF alpha/TGFA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1360)|
|Similar Products From
|Anti-TGF alpha/TGFA Antibody may replace the following items: sc 10212|sc 131448|sc 1338|sc 14144|sc 160179|sc 21225|sc 27155|sc 31048|sc 36|sc 36 X|sc 374433|sc 57447|sc 6458|sc 82970|sc 85662|sc 9043.|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human TGF alpha(73-89aa CHSGYVGARCEHADLLA), different from the related mouse and rat sequences by one amino acid.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For TGFA (Source: Uniprot.org, NCBI)
|NCBI Gene Id||7039|
|Species Of This Entry||Human|
|Protein Name||Protransforming growth factor alpha|
|Alternative Names||TGF-alpha|protransforming growth factor alpha; TFGA; TGFA; TGFalpha; TGF-alpha; transforming growth factor, alpha; transforming growth factor-alpha|
|Post Tranlational Modifications||Phosphorylation; Oxidation; Cleavage|
|Subcellular Localization||[Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.|
|Gene Location||2p13.3, on Chromasome 2, gene sequence: NC_000002.12 (70447284..70553826, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For TGFA (Source: Uniprot.org, NCBI)
|Protein Function||TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.|
|Interacting Proteins||EGFR; Magi3; NKD2; SGTA|
|Related Diseases||Cleft Palate; Cleft Lip; Neoplasms; Malignant Neoplasms; Carcinoma; Congenital Abnormality; Cleft Palate With Cleft Lip; Dysequilibrium Syndrome; Cell Transformation, Neoplastic; Congenital Absence; Adenocarcinoma; Diabetes Mellitus; Tumor Angiogenesis; Malignant Paraganglionic Neoplasm; Obesity; Carcinogenesis; Malignant Squamous Cell Neoplasm; Maternal Exposure; Malignant Neoplasm Of Breast; Diabetes Mellitus, Non-insulin-dependent|
|Related Pathways||Transport; Pathogenesis; Secretion; Angiogenesis; Cell Proliferation; Localization; Cell Death; Fertilization; Cell Cycle; Cell Killing; Keratinization; Regulation Of Protein Kinase Activity; Programmed Cell Death; Secondary Growth; Aging; Palate Development; Ossification; Intestinal Absorption; Embryo Development; Negative Regulation Of Protein Kinase Activity|
|Background||Transforming growth factor alpha(TGF-alpha) is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects . TGFalpha stimulates neural cell proliferation in the adult injured brain. TGFalpha was cited in the 2001 NIH Stem Cell report to the U.S. Congress as promising evidence for the ability of adult stem cells to restore function in neurodegenerative disorders.|
|Scientific References||PMID: 6088071 by Derynck R., et al. Human transforming growth factor-alpha: precursor structure and expression in E. coli.|
PMID: 2464748 by Jakowlew S.B., et al. A novel low molecular weight ribonucleic acid (RNA) related to transforming growth factor alpha messenger RNA.
Our Boster Quality Guarantee for Anti-TGF alpha/TGFA Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti TGF alpha (PA1360) at 0.5ug/ml
Lane 1: Recombinant Human TGF a Protein 10ng
Lane 2: Recombinant Human TGF a Protein 5ng
Lane 3: Recombinant Human TGF a Protein 2.5ng
Predicted bind size: 6KD
Observed bind size: 6KD
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
Other Recommended Resources
Here are featured tools and databases that you might find useful.
Total number of citations: 3
|Zhang W, Chen Dq, Qi F, Wang J, Xiao Wy, Zhu Wz. J Cardiovasc Pharmacol. 2010 Jan;55(1):96-105. Doi: 10.1097/Fjc.0B013E3181C9548B. Inhibition Of Calcium-Calmodulin-Dependent Kinase Ii Suppresses Cardiac Fibroblast Proliferation And Extracellular M...||PubMed ID 19935079|
|Li Xn, Pan X, Qiu D. Int J Clin Exp Med. 2014 Dec 15;7(12):5324-9. Ecollection 2014. Imbalances Of Th17 And Treg Cells And Their Respective Cytokines In Copd Patients By Disease Stage.||PubMed ID 25664038|
|Ruan Gp, Xu F, Li Za, Zhu Gx, Pang Rq, Wang Jx, Cai Xm, He J, Yao X, Ruan Gh, Xu Xm, Pan Xh. Plos One. 2013 Dec 18;8(12):E83507. Doi: 10.1371/Journal.Pone.0083507. Ecollection 2013. Induced Autologous Stem Cell Transplantation For Treatment Of Rab...||PubMed ID 24367598|
Order Product (PA1360)
Domestically in USA and Canada, ships next business day if available in stock.
Note: sample size takes longer to process, average 5-7 days.
All Boster antibodies and ELISA kits are guaranteed to meet the specifications on the data sheet.See Details
Download troubleshooting handbooks for IHC, Western blot and ELISA for FREE.Download Free PDFs Now
Guaranteed product quality
We promise all of our products perform as described in datasheets.