Anti-Unc93b UNC93B1 Antibody

Product Name

Anti-Unc93b UNC93B1 Antibody

View all UNC93B1 Antibodies

SKU/Catalog Number

A03864

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Unc93b UNC93B1 Antibody (Catalog # A03864). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Unc93b antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Unc93b UNC93B1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03864)

Host

Rabbit

Contents

Unc93b Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Unc93b antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human Unc93b. The immunogen is located within amino acids 80 - 130 of Unc93b.

Cross-reactivity

Multiple isoforms of Unc93b are known to exist. This antibody will not cross-react with Unc93a.

Reactive Species

A03864 is reactive to UNC93B1 in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

66.6 kDa

Background of UNC93B1

The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A03864 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Unc93b antibody can be used for the detection of Unc93b by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information UNC93B1

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