Rabbit IgG polyclonal antibody for Vascular endothelial growth factor D(FIGF) detection. Tested with WB, IHC-P in Human;Mouse;Rat. Cited in 1 publication(s).
Anti-VEGFD/FIGF Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-VEGFD/FIGF Antibody
See all VEGFD primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for FIGF detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. FIGF information: Molecular Weight: 40444 MW; Subcellular Localization: Secreted; Tissue Specificity: Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.|
|Cite This Product||Anti-VEGFD/FIGF Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1332)|
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|Anti-VEGFD/FIGF Antibody may replace the following items: sc 13085|sc 25784|sc 27130|sc 27131|sc 373866|sc 7602|sc 7603.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human VEGFD(101-115aa VIDEEWQRTQCSPRE), identical to the related rat and mouse sequences.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For VEGFD (Source: Uniprot.org, NCBI)
|NCBI Gene Id||2277|
|Species Of This Entry||Human|
|Protein Name||Vascular endothelial growth factor D|
|Superfamily||PDGF/VEGF growth factor family|
|Alternative Names||VEGFD|Vascular endothelial growth factor D|
|Post Tranlational Modifications||Cleavage on pair of basic residues; Disulfide bond; Glycoprotein|
|Gene Location||Xp22.2, on Chromasome X, gene sequence: NC_000023.11 (15345596..15384413, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For VEGFD (Source: Uniprot.org, NCBI)
|Protein Function||Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.|
|Tissue Specificity||Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.|
|Background||C-fos induced growth factor(FIGF)(or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor(PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. Analyzing by Northern blotting, Yamada et al.(1997) symbolized VEGFD, was expressed as a 2.2-kb transcript with highest expression in lung, heart, small intestine, and fetal lung, and lower levels in skeletal muscle, colon, and pancreas. And Achen et al.(1998) concluded that VEGFD was most closely related to VEGFC by virtue of the presence of N- and C-terminal extensions that were not found in other VEGF family members. Stacker et al.(2001) showed that VEGFD can induce tumor angiogenesis through VEGFR2 and tumor lymphangiogenesis through VEGFR3, whereas VEGF, which does not activate VEGFR3, induces only tumor angiogenesis.|
|Scientific References||PMID: 9205122 by Yamada Y., et al. Molecular cloning of a novel vascular endothelial growth factor, VEGF-D.|
PMID: 9479493 by Rocchigiani M., et al. Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes.
Our Boster Quality Guarantee for Anti-VEGFD/FIGF Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: SW620 Cell Lysate
Lane 2: COLO320 Cell Lysate
Lane 3: 6T-CEM Cell Lysate
Lane 4: HT1080 Cell Lysate
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