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- Table of Contents
CHEK2 Antibodies
AND CHEK2 ELISA kits, CHEK2 Proteins
Many biological assays use antibodies to detect CHEK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHEK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHEK2 antibodies...
Designing a Western blot for CHEK2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CHEK2 Western Blot GuideCHEK2 Infographic by Boster Bio
All CHEK2 Products
Product
Figures
Specificity
Applications
Price
Anti-Chk2/CHEK2 Antibody Picoband®
1 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9692
100 μg/vial
Cat # PB9692
100 μg/vial
Anti-CHEK2 Antibody (N-term)
1 Citations
Human
Flow Cytometry, IF, IHC-P, WB
$299
Cat # A00277-1
80 µl
Cat # A00277-1
80 µl
Dog, Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, WB
$523
Cat # M00277-1
100 µl
Cat # M00277-1
100 µl
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M00277-2
100 µl
Cat # M00277-2
100 µl
Human, Mouse
ELISA, IP, IF, IHC, WB
$146
Cat # M00277-4
20μL, 40μL, 100μL, 200μL
Cat # M00277-4
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00277-3
20μL, 40μL, 100μL, 200μL
Cat # M00277-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2374
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2374
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$540
Cat # EKC2373
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2373
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2194
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2194
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2022
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2022
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1113
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1113
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00277T387-1
100ul
Cat # A00277T387-1
100ul
Human, Monkey, Mouse, Rat
ELISA, IF, WB
$380
Cat # A00277T383
100ul
Cat # A00277T383
100ul
CHEK2 Overview
Facts about Serine/threonine-protein kinase Chk2.
Serine/threonine-protein kinase Chk2 (CHEK2)
Serine/threonine-protein kinase that's required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. Following activation, phosphorylates numerous effectors preferentially in the consensus sequence [L-X- R-X-X-S/T].
Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 that's involved in G2/M cell cycle arrest.
Gene Information
| Human | |
|---|---|
| Gene Name: | CHEK2 |
| Uniprot: | O96017 |
| Entrez: | 11200 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CDS1; CHEK2; CHK2 checkpoint homolog (S. pombe); Chk2; EC 2.7.11; EC 2.7.11.1; HuCds1; LFS2; PP1425; Rad53; S.pombe) homolog
Molecular Weight
Mass (kDA):
60.915 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q12.1 |
| Sequence: | 22; NC_000022.11 (28687743..28741866, complement) |
Tissue Specificity
High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues.
Subcellular Localizations
[Isoform 2]: Nucleus. Isoform 10 is present throughout the cell.; [Isoform 4]: Nucleus.; [Isoform 7]: Nucleus.; [Isoform 9]: Nucleus.; [Isoform 12]: Nucleus.; Nucleus, PML body. Nucleus, nucleoplasm. Recruited into PML bodies together with TP53.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Neoplasms
- Malignant Neoplasm Of Ovary
- Colorectal Cancer
- Malignant Neoplasm Of Prostate
- Ovarian Neoplasm
- Colorectal Neoplasms
- Li-fraumeni Syndrome
- Carcinoma
- Prostatic Neoplasms
- Hereditary Breast Carcinoma
Interacting Proteins
- AATF
- FAM84B
- GINS2
- IL24
- PER3
- PLK1
- PPP2R5A
- PPP2R5B
- PPP2R5E
- RB1
Pathways
- Cell Cycle
- Dna Repair
- Cell Cycle Checkpoint
- Cell Cycle Arrest
- Methylation
- Pathogenesis
- Localization
- Cell Death
- Dna Damage Checkpoint
- Cell Proliferation
- Mismatch Repair
- Double-strand Break Repair
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHEK2
bosterbio.com/bosterbio-gene-info-cards/CHEK2
References
PMID: 9836640 by Matsuoka S., et al. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
PMID: 9889122 by Blasina A., et al. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase.