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Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 together with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T- cells.
|tumor necrosis factor family|
|Sequence:||X; NC_000023.11 (136648158..136660390)|
Specifically expressed on activated CD4+ T- lymphocytes.
Cell membrane; Single-pass type II membrane protein. Cell surface.; [CD40 ligand, soluble form]: Secreted. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
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