Dual specificity protein phosphatase 6 (DUSP6)

Inactivates MAP kinases.

Has a specificity for the ERK family (PubMed:9858808).

Plays an essential role in relieving chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity).