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- Table of Contents
KEAP1 Antibodies
AND KEAP1 ELISA kits, KEAP1 Proteins
Many biological assays use antibodies to detect KEAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KEAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KEAP1 antibodies...
Designing a Western blot for KEAP1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KEAP1 Western Blot GuideKEAP1 Infographic by Boster Bio
All KEAP1 Products
Product
Figures
Specificity
Applications
Price
Anti-KEAP1 Antibody Picoband®
15 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00514-3
100 μg/vial
Cat # A00514-3
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00514-1
20μL, 40μL, 100μL, 200μL
Cat # M00514-1
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M00514
100 µl
Cat # M00514
100 µl
KEAP1 Overview
Facts about Kelch-like ECH-associated protein 1.
Kelch-like ECH-associated protein 1 (KEAP1)
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus leading to the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol.
Targets PGAM5 for ubiquitination and degradation by the proteasome. .
Gene Information
| Human | |
|---|---|
| Gene Name: | KEAP1 |
| Uniprot: | Q14145 |
| Entrez: | 9817 |
Family
| Belongs to: |
|---|
| KEAP1 family |
Alternative Names
INrf2; INrf2MGC9454; Keap1; kelch-like ECH-associated protein 1; Kelch-like protein 19; KIAA0132MGC4407; KLHL19Cytosolic inhibitor of Nrf2; MGC10630; MGC1114; MGC20887
Molecular Weight
Mass (kDA):
69.666 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (10486125..10503356, complement) |
Tissue Specificity
Broadly expressed, with highest levels in skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus. Mainly cytoplasmic (PubMed:15601839). In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62 (PubMed:20452972).
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinogenesis
- Inflammation
- Carcinoma
- Neurodegenerative Disorders
- Malignant Neoplasm Of Lung
- Cell Transformation, Neoplastic
- Lung Neoplasms
- Liver Carcinoma
- Non-small Cell Lung Carcinoma
- Adenocarcinoma
- Parkinson Disease
Interacting Proteins
- AMER1
- ASPA
- CCNB1IP1
- DPP3
- ETF1
- FAM117B
- IKBKB
- Ikbkb
- Irf1
- LSM3
Pathways
- Localization
- Cell Death
- Pathogenesis
- Response To Oxidative Stress
- Neuroprotection
- Cell Proliferation
- Conjugation
- Autophagy
- Drug Resistance
- Aging
- Cell Cycle
- Nuclear Export
- Sensitization
PTMs
- Ubiquitination
- Phosphorylation
- Oxidation
- Reduction
- Methylation
- Nitrosylation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KEAP1
bosterbio.com/bosterbio-gene-info-cards/KEAP1
References
PMID: 14585973 by Zhang D.D., et al. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress.
PMID: 15379550 by Strachan G.D., et al. Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.
7 Publications of Boster KEAP1 Antibodies & ELISA Kits
- PubMed ID: 10.1039/C6RA14831J, Individual and combined antioxidant effects of ginsenoside F2 and cyanidin-3-O-g...
- PubMed ID: 10.1016/j.carbpol.2018.01.075, Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress da...
- PubMed ID: 10.1002/jcp.26769, Andrographolide protects chondrocytes from oxidative stress injury by activation...
- PubMed ID: 33359640, Li D,Bai X,Jiang Y,Cheng Y.Butyrate alleviates PTZ-induced mitochondrial dysfunc...
- PubMed ID: 26339340, Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary f...
- PubMed ID: 29744366, Zhu X, Chen Y, Chen Q, Yang H, Xie X. J Diabetes Res. 2018 Mar 21;2018:6730315. ...
- PubMed ID: 25288107, Deng Y, Zhu J, Mi C, Xu B, Jiao C, Li Y, Xu D, Liu W, Xu Z. Neurotox Res. 2015 F...
*More publications can be found for each product on its corresponding product page