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- Table of Contents
Prelamin-A/C Antibodies
AND LMNA ELISA kits, Prelamin-A/C Proteins
Many biological assays use antibodies to detect Prelamin-A/C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prelamin-A/C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prelamin-A/C antibodies...
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LMNA Infographic by Boster Bio
All LMNA Products
Product
Figures
Specificity
Applications
Price
Anti-Lamin A + C/LMNA Antibody Picoband®
8 Citations 16 Q&As
Human, Mouse, Rat
IHC, ICC, WB
$370
Cat # PA1103
100 μg/vial
Cat # PA1103
100 μg/vial
Anti-Lamin A+C/LMNA Antibody Picoband®
3 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9280
100 μg/vial
Cat # PB9280
100 μg/vial
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00438
100 μl
Cat # M00438
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1336
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1336
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2082
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2082
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2633
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2633
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00438S22-1
100ul
Cat # A00438S22-1
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00438S392
100ul
Cat # A00438S392
100ul
Anti-Lamin A/C Rabbit Monoclonal Antibody
5 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00438-5
100 μl/vial
Cat # M00438-5
100 μl/vial
Human, Mouse, Rat
IHC, WB
$370
Cat # M00438-6
100 μg/vial
Cat # M00438-6
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00438-8
20μL, 40μL, 100μL, 200μL
Cat # M00438-8
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P00438
100 μl/vial
Cat # P00438
100 μl/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P00438-2
100 μl/vial
Cat # P00438-2
100 μl/vial
LMNA Overview
Facts about Prelamin-A/C.
Prelamin-A/C (LMNA)
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to present a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equivalent amounts in the lamina of mammals.
Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal maturation of peripheral nervous system and skeletal muscle and also for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513).
Gene Information
| Human | |
|---|---|
| Gene Name: | LMNA |
| Uniprot: | P02545 |
| Entrez: | 4000 |
Family
| Belongs to: |
|---|
| intermediate filament family |
Alternative Names
CDCD1; CDDC; CMD1A; CMT2B1; dilated 1A (autosomal dominant); EMD2; FPLD; HGPSFPL; lamin A/C; lamin A/C-like 1; lamin-A/C; LDP1; LFP; LGMD1B; limb girdle muscular dystrophy 1B (autosomal dominant); LMN1IDC; LMNC; LMNL1; prelamin-A/C; PRO1,70 kDa lamin; progeria 1 (Hutchinson-Gilford type); renal carcinoma antigen NY-REN-32
Molecular Weight
Mass (kDA):
74.139 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q22 |
| Sequence: | 1; NC_000001.11 (156082546..156140089) |
Tissue Specificity
In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
Subcellular Localizations
Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.; [Isoform C]: Nucleus speckle.
Diseases
- Progeria
- Lipodystrophy
- Cardiomyopathies
- Muscular Dystrophy
- Dystrophy
- Cardiomyopathy, Dilated
- Acquired Partial Lipodystrophy
- Familial Partial Lipodystrophy
- Muscular Dystrophy, Emery-dreifuss
- Premature Aging Syndrome
- Insulin Resistance
- Diabetes Mellitus
- Myopathy
Interacting Proteins
- ALOX12
- DUSP13
- H2AFX
- HIST2H3A
- KRTAP10-7
- LMNB1
- LMNB2
- PASK
- SUN2
- SYCE1
Pathways
- Aging
- Pathogenesis
- Senescence
- Localization
- Cardiac Conduction
- Cell Cycle
- Chromatin Organization
- Mitosis
- Dna Replication
- Dna Repair
- Interphase
- Cellular Senescence
- Cell Proliferation
PTMs
- Farnesylation
- Phosphorylation
- Cleavage
- Methylation
- Prenylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LMNA
bosterbio.com/bosterbio-gene-info-cards/LMNA
References
PMID: 3453101 by McKeon F.D., et al. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins.
PMID: 3462705 by Fisher D.Z., et al. cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.
8 Publications of Boster Prelamin-A/C Antibodies & ELISA Kits
- PubMed ID: 10.18632/oncotarget.19845, Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angi...
- PubMed ID: 10.1016/j.prp.2014.11.008, Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is...
- PubMed ID: 10.1016/j.ejphar.2019.172619, Medical findings of nasopharyngeal carcinoma patients and anti-tumor benefits of...
- PubMed ID: 10.1016/j.biocel.2013.07.022, NBPF is a potential DNA-binding transcription factor that is directly regulated ...
- PubMed ID: 33859765, Li D,Liu J,Yang C,Tian Y,Yin C,Hu L,Chen Z,Zhao F,Zhang R,Lu A,Zhang G,Qian A.Ta...
- PubMed ID: 26429910, 714: Concentration-dependent Effects of Nuclear Lamins on Nuclear Size in Xenop...
- PubMed ID: 21053261, Yang Lm, Liu Xl, Zhu Qt, Zhang Y, Xi Tf, Hu J, He Cf, Jiang L. J Biomed Mater Re...
- PubMed ID: 25240403, Liu J, Ma J, Wu Z, Li W, Zhang D, Han L, Wang F, Reindl Km, Wu E, Ma Q. Bmc Canc...
*More publications can be found for each product on its corresponding product page