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- Table of Contents
7 Citations
10 Citations 16 Q&As
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13 Citations 16 Q&As
Facts about Mitogen-activated protein kinase 3.
They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.
Human | |
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Gene Name: | MAPK3 |
Uniprot: | P27361 |
Entrez: | 5595 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11; ERK1; ERK-1; ERK1p44-MAPK; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; HS44KDAP; HUMKER1A; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; MAPK3; MGC20180; Microtubule-associated protein 2 kinase; Mitogen-activated protein kinase 1; mitogen-activated protein kinase 3; P44ERK1; p44-ERK1; p44mapk; PRKM3; PRKM3EC 2.7.11.24
Mass (kDA):
43.136 kDA
Human | |
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Location: | 16p11.2 |
Sequence: | 16; NC_000016.10 (30114105..30123309, complement) |
Cytoplasm. Nucleus. Membrane, caveola. Autophosphorylation at Thr-207 promotes nuclear localization.
If you are looking for a high-affinity antibody to the MAPK3 protein, you have come to the right place. Boster offers high-affinity primary antibodies that are validated by ELISA, Western Blotting, and Immunohistochemistry. These antibodies are trusted by the research community for their high affinity and high-specificity. Here is a list containing the best antibodies for the MAPK3 Protein.
A MAPK3 marker has the potential to help doctors diagnose diseases. Researchers can use this marker in order to determine if a drug they're testing is actually effective or if money is being wasted. The MAPK3 marker has been used by many companies to test breast cancer. Randox Life Sciences is just one of these companies. The MAPK3 marker, a protein involved in cell proliferation, is known as a protein. It is actually involved with the growth of cancer-cells.
Randox Life Sciences offers raw materials for assay development. The company produces high standards in antibodies, fragments and recombinant or conjugate proteins. The Randox Research and Randox Laboratories provide these products to diagnostics markets. These companies are committed to providing efficient, cost-effective and accurate R&D solutions that benefit the biomedical field.
The MAPK3 mark is used in many areas, including tumor biology, cell therapy and cancer prevention. It is particularly useful in predicting ovarian cancer, which is a leading cause of death in women. It can also serve as an immunoassay to detect the progression in diseases, such inherited genetic disorders and cardiovascular disease. The company makes antibodies that target MAPK3 and has many potential applications.
High-affinity primary antibodies using the MAKK3 mark provide additional evidence for the disease. The MAPK3 protein was associated with multiple neuronal pathways including the NFKB pathway, NFKB, and p38 MAPK. These alterations have been shown to be linked to MS, Parkinson's Disease, and Glioma. The study suggests that antibodies may be useful in identifying disease-related protein.
While the MAPK3 marker is known to be associated with several cellular pathways, this method cannot be applied to the identification of a single protein. However, affinity agents that bind the same protein as the marker MAPK3 could be a way to unlock the future for the microarray. For protein-specific screening, dimerized antibody could also be used. This technology could also help to develop new nanobody microarrays.
MAPK3 antibody has been generated from rabbits immunized against synthetic peptide. The antibody is supplied in PBS containing 0.09% sodium azide. It is purified with either protein A column or by peptide affinity purification. Multiple studies have been conducted with the MAPK3 antigen to investigate leishmaniasis. This research could lead to a new treatment.
After purification, the protein was subject to immunoblot assays. Immunoblotting was also performed using a monoclonal antibody against mouse. These experiments revealed the MAPK3 protein at 48 kDa was detected using His6-mAb. Additional information is provided by the original uncropped photos. High-affinity primary antibodies can be used to further analyze the MAPK3 marker.
These ELISA kits detect the presence of TIMP-1 and Klebsiella pneumoniae, three pathogenic bacteria. These tests use natural TIMP-1, which has 22 KDa molecular mass. Hence, they are suitable for detecting the presence of both pathogens and their toxins.
Boster Bio specializes developing picogram-sensitivity ELISA Kits and IHC optimised polyclonal Antibodies. They offer a wide range of over 12,000 antibodies validated for ELISA, WB, and Flow, and validated against a panel of 250 tissues and untransfected cell lines. This ensures high affinity. The company can provide technical support for products.
PMID: 7687743 by Charest D.L., et al. Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.
PMID: 1540184 by Owaki H., et al. Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page