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- Table of Contents
18 Citations 16 Q&As
29 Citations 11 Q&As
6 Citations 18 Q&As
14 Citations 17 Q&As
1 Citations 4 Q&As
Facts about Myeloperoxidase.
From the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, along with other toxic intermediates that greatly enhance PMN microbicidal activity. .
Human | |
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Gene Name: | MPO |
Uniprot: | P05164 |
Entrez: | 4353 |
Belongs to: |
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peroxidase family |
EC 1.11.1; EC 1.11.1.7; Lactoperoxidase; MPO; Myeloperoxidase
Mass (kDA):
83.869 kDA
Human | |
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Location: | 17q22 |
Sequence: | 17; NC_000017.11 (58269855..58280935, complement) |
Lysosome.
The Boster Bio: MPO Marker is a multi-functional and inexpensive protein assay instrument. It can be used with DyLight 488-labeled second antibody Hoechst 33258, which allows for the exact detection of protein. This marker is suitable for all kinds of studies and applications and is available to scientists across the world. Below are the benefits and advantages of this marker.
Several studies have demonstrated the advantages of MPO. Several studies have demonstrated the benefits of. It is a DC activation regulator that has been proven to limit excessive T-cell immunity. The MPO marker is a beneficial one with many benefits, including the prevention of inflammation and fibrosis. However, the precise mechanisms that cause the effects of MPO are not fully understood. However, its presence in bloodstream has been linked to various illnesses such as cancer, diabetes and cardiovascular diseases.
The MPO marker has been investigated for its ability to diagnose and predict cardiovascular diseases. Its specificity and sensitivity were similar to those of CRP and Tn. Although the results of this study were encouraging however, further research is needed to determine if MPO-guided therapy are beneficial. The MPO marker is a promising tool to improve the patient's care. We will now look at some of the benefits of MPO-guided therapies.
In a recent study, Wagner, et al. investigated the MPO levels in fecal samples of 38 patients suffering from IBD to see if it served as an indicator of treatment effectiveness. Whether or not patients had an elevated level of MPO could indicate whether they had a complete or partial response to their treatment. In another study, Peterson, et al., measured MPO levels in 44 healthy individuals and 18 IBD patients. Both studies showed that the MPO levels in IBD patients were significantly higher than those of healthy subjects. They also noted that the MPO marker could distinguish between IBD and healthy patients.
In the Cleveland Clinic Foundation study of 2003, MPO was demonstrated to be a sensitive indicator of myocardial injury for patients suffering from chest pain. In another study, conducted by a larger cohort of 1090 patients MPO levels were linked to an increased risk of cardiovascular mortality. In comparison to troponin-T levels, elevated MPO levels were related to an increased risk of suffering from cardiovascular disease. These results highlight the importance of MPO in predicting cardiovascular events.
MPO is an enzyme in mammals that inhibits adaptive and innate immune responses. MPO blocks DC maturation and limits injurious T-cell responses. Several studies have shown that MPO is an important therapeutic target. Thus, MPO inhibitors have been an important step in the treatment of inflammatory and immune diseases. The research also reveals the potential advantages of MPO as a biomarker for clinical practice.
Boster can help you in your research, whether you're conducting an ELISA preliminary analysis to determine if your antibody is specific enough for a particular protein or an research study in immunohistochemistry. Boster Bio provides high-affinity antibodies that have been tested by Western Blotting, Immunohistochemistry, and ELISA. Boster's antibodies have been tested against mouse and human samples.
Hoechst 33258 dye kits emit blue fluorescence when bound by DsDNA. Although it has similar applications to Hoechst 33258 (H-1399) however, this dye is less cell-permeant. Both dyes are available in a solution and can be utilized to detect DNA in cell samples. Here are a few of the more popular uses.
This MPO marker dye kit gives a blue indicator that distinguishes between non-apoptotic and apoptotic cells. The cracking of DNA is what distinguishes between apoptotic and non-apoptotic cells. The dye is non-toxic and is able to bind to DNA molecules, allowing it to show a bright blue color in cells that are dying. It also has a second dye 6-Carboxyfluorescein diacetate, which helps distinguish apoptotic cells.
The CD5 (cholecystokinin-receptor) is an important member the cysteine rich superfamily of scavenger receptors which includes membrane-anchored and secreted proteins. These proteins are typically found in immune system cells. The transmembrane glycoprotein of type I has three SRCR domains. It may also act as an antagonist for T-cell proliferation. Alternative splicing can result in many transcript variations.
PMID: 3029127 by Morishita K., et al. Molecular cloning and characterization of cDNA for human myeloperoxidase.
PMID: 2444596 by Morishita K., et al. Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor.
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page