Poly [ADP-ribose] polymerase 1 (PARP1)

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin structure and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway resulting in the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272).

With EEF1A1 and TXK, forms a complex that serves as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its own transcription, and is consequently involved importantly in Th1 cytokine production (PubMed:17177976). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272).