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- Table of Contents
PCNA Antibodies
AND PCNA ELISA kits, PCNA Proteins
Many biological assays use antibodies to detect PCNA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PCNA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PCNA antibodies...
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PCNA Infographic by Boster Bio
All PCNA Products
Product
Figures
Specificity
Applications
Price
Anti-PCNA Antibody (Monoclonal, PC 10)
200 Citations 17 Q&As
Human, Mouse, Rat
IHC, ICC, WB
$370
Cat # MA1083
100 μg/vial
Cat # MA1083
100 μg/vial
Anti-PCNA Rabbit Monoclonal Antibody
14 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00125-1
100 μl
Cat # M00125-1
100 μl
Anti-PCNA Antibody Picoband®
39 Citations 5 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00125
100 μg/vial
Cat # A00125
100 μg/vial
Anti-PCNA Antibody Picoband® (monoclonal, 2G2)
51 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00125-3
100 μg/vial
Cat # M00125-3
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00125-5
20μL, 40μL, 100μL, 200μL
Cat # M00125-5
20μL, 40μL, 100μL, 200μL
PCNA Overview
Facts about Proliferating cell nuclear antigen.
Proliferating cell nuclear antigen (PCNA)
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities.
Must be loaded onto DNA in order to be able to stimulate APEX2. Plays a vital role in DNA damage response (DDR) by being conveniently positioned in the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902).
Gene Information
| Human | |
|---|---|
| Gene Name: | PCNA |
| Uniprot: | P12004 |
| Entrez: | 5111 |
Family
| Belongs to: |
|---|
| PCNA family |
Alternative Names
cyclin; DNA polymerase delta auxiliary protein; MGC8367; proliferating cell nuclear antigen
Molecular Weight
Mass (kDA):
28.769 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p12.3 |
| Sequence: | 20; NC_000020.11 (5114953..5126622, complement) |
Subcellular Localizations
Nucleus. Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Hyperplasia
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Malignant Squamous Cell Neoplasm
- Carcinogenesis
- Adenocarcinoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Cell Invasion
- Mammary Neoplasms
Interacting Proteins
- ALDOA
- ANG
- ANXA2
- B2M
- CDKN1A
- CDKN2A
- CDT1
- CHAF1A
- DDIT4L
- EEF1A1
Pathways
- Cell Proliferation
- Cell Cycle
- Dna Replication
- S Phase
- Regeneration
- Dna Repair
- Localization
- Cell Growth
- Cell Death
- Angiogenesis
- Pathogenesis
- Cell Cycle Arrest
- Liver Regeneration
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Methylation
- Sumoylation
- Acetylation
- Dephosphorylation
- Reduction
- Oxidation
- Biotinylation
Research Areas
- Autophagy
- Base Excision Repair
- Cellular Markers
- DNA Repair
- Loading Controls
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PCNA
bosterbio.com/bosterbio-gene-info-cards/PCNA
References
PMID: 2882507 by Almendral J.M., et al. Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.
PMID: 2565339 by Travali S., et al. Structure of the human gene for the proliferating cell nuclear antigen.
162 Publications of Boster PCNA Antibodies & ELISA Kits
- PubMed ID: 10.3892/or.16.5.1021, Histological type of oncogenity and expression of cell cycle genes in tumor cell...
- PubMed ID: 10.3892/ol.2014.1803, Abscopal antitumor immune effects of magnet‑mediated hyperthermia at a high th...
- PubMed ID: 10.3748/wjg.v13.i18.2615, Pancreas duodenal homeobox-1 expression and significance in pancreatic cancer
- PubMed ID: 10.24272/j.issn.2095-8137.2020.375, LIN28A inhibits DUSP family phosphatases and activates MAPK signaling pathway to...
- PubMed ID: 10.2147/CMAR.S302084, Grape Seed Proanthocyanidins (GSPs) Inhibit the Development of Cutaneous Squamou...
- PubMed ID: 10.1186/1756-9966-27-60, Thalidomide influences growth and vasculogenic mimicry channel formation in mela...
- PubMed ID: 10.1155/2013/905715, The Effects of High-Dose Qinggan Huoxue Recipe on Acute Liver Failure Induced by...
- PubMed ID: 10.1111/j.1872-034X.2008.00456.x, Differential expression of the genes involved in amino acids and nitrogen metabo...
- PubMed ID: 10.1111/j.1601-0825.2010.01655.x, Synthetic radiation‐inducible promoters mediated HSV‐TK/GCV gene therapy in ...
- PubMed ID: 10.1111/j.1600-0714.2008.00728.x, Increased expression of focal adhesion kinase correlates with cellular prolifera...
- PubMed ID: 10.1097/CEJ.0b013e32833ebaa0, Downregulation of Id1 by small interfering RNA in prostate cancer PC3 cells in v...
- PubMed ID: 10.1089/scd.2021.0100, Human Exosomes Accelerate Cutaneous Wound Healing by Promoting Collagen Synthesi...
- PubMed ID: 10.1080/02713683.2019.1657463, The Evaluation of TUNEL, PCNA and SOX2 Expressions in Lens Epithelial Cells of C...
- PubMed ID: 10.1042/BA20100038, Tumstatin45‐132‐TNFα suppresses tumour growth through anti‐angiogenic eff...
- PubMed ID: 10.1039/D1MO00387A, 1H-NMR based metabolic study of MMTV-PyMT mice along with pathological progress ...
- PubMed ID: 10.1039/C5RA22371G, Reparative activity of costunolide and dehydrocostus in a mouse model of 5-fluor...
- PubMed ID: 10.1038/srep20046, Involvement of MicroRNA-210 Demethylation in Steroid-associated Osteonecrosis of...
- PubMed ID: 10.1016/j.yexmp.2005.07.004, Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo
- PubMed ID: 10.1016/j.phymed.2021.153804, Bioactive constituents of Mosla chinensis-cv. Jiangxiangru ameliorate inflammati...
- PubMed ID: 10.1016/j.neulet.2011.12.057, Lateral hypothalamic area mediated the aggravated effect of microinjection of Ba...
- PubMed ID: 10.1016/j.jconrel.2017.09.007, Supramolecular cisplatin-vorinostat nanodrug for overcoming drug resistance in c...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page