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- Table of Contents
Facts about Pericentrin.
Is an integral component of the pericentriolar material (PCM). May play an essential role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.
Human | |
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Gene Name: | PCNT |
Uniprot: | O95613 |
Entrez: | 5116 |
Belongs to: |
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No superfamily |
Kendrin; KIAA0402; MOPD2; PCN; PCNT2pericentrin B; PCNTB; pericentrin 2 (kendrin); pericentrin; pericentrin, kendrin (KIAA0402)10KENPCTN2; pericentrin-2; pericentrin-380; pericentrin-B; SCKL4kendrin
Mass (kDA):
378.037 kDA
Human | |
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Location: | 21q22.3 |
Sequence: | 21; NC_000021.9 (46324122..46445769) |
Expressed in all tissues tested, including placenta, liver, kidney and thymus.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.
PMID: 11171385 by Li Q., et al. Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1.
PMID: 10823944 by Flory M.R., et al. Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin.