This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
2 Citations 5 Q&As
Facts about Phosphatidylinositol 3-kinase regulatory subunit alpha.
Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429).
Human | |
---|---|
Gene Name: | PIK3R1 |
Uniprot: | P27986 |
Entrez: | 5295 |
Belongs to: |
---|
PI3K p85 subunit family |
GRB1; GRB1PI3-kinase subunit p85-alpha; p85; p85-ALPHA; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase, regulatory, 1; phosphatidylinositol 3-kinase-associated p-85 alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI 3Kinase p85 alpha; PI 3-Kinase p85 alpha; PI3K regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PIK3R1; PtdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory s
Mass (kDA):
83.598 kDA
Human | |
---|---|
Location: | 5q13.1 |
Sequence: | 5; NC_000005.10 (68215737..68301821) |
Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
PIK3R1 targets miR-1065a-5p, the herpes virus type 1 thymidine promor. This article focuses on the potential of this marker and its application in research. This article will also explain the ways scientists can use this marker to study the functions of this gene. This article was written by scientists from every discipline and in all countries.
The PIK3R1 gene encodes proteins that have the phosphorylated tyrosine atoms. The nine 3' exons are present in all three forms of the gene. Mutations in this gene result in the loss of a component of the binding domain p110. There are no treatment options currently are available for PIK3R1 mutants.
The PIK3R1R348* protein triggers JNK signaling in the nucleus. It activates JNK via nuclear translocation, phosphorylation of MLK3 and MKK7. These results support the idea that JNK signaling is dependent upon the PIK3R1 genes. These findings must be confirmed with more research.
Besides regulating cell proliferation, PIK3R1 is also implicated in Hepatocellular carcinoma (HCC). The exact function of PIK3R1 is unknown in HCC. However, scientists have made some important discoveries. Researchers are able to better understand HCC's molecular mechanisms by studying the PIK3R1 marker gene.
The PIK3R1 gene can be used to study the role of the MAPK pathway. PIK3R1R348 is involved in cell proliferation and invasion and reduces the its sensitivity to apoptosis. It activates the ERK, JNK pathways. These pathways are crucial for many different types of cancer research. If you're interested in the PIK3R1 gene, you must read these articles.
PIK3R1 is an important gene in glucocorticoid-mediated glucose and protein metabolism. Elimination of this gene impedes the growth and survival of B cells in the periphery. This gene is essential in controlling Ig class switch recombination, and the differentiation of plasma cells. PIK3R1 also plays a critical role in maturing antibodies and Ig class switching. The marker can be used to determine if someone has a blood disorder, or cancer.
Overexpression of PIK3R1 is not recommended for all patients suffering from HCC. Hyperactive PI3K signaling has been linked with immune deficiency, which is not an outcome that is desirable. It is important to understand the potential benefits this gene might bring as soon as it is possible. It is best to test the gene for HCC by using it as a biomarker for an experiment where the patient's immune system is monitored.
The PIK3R1 gene is a part of the PI3K regulatory subunit family. It encodes a polypeptide of 724 amino acids. The protein plays a vital role in the metabolism of insulin, and is associated with resistance to insulin. It is a widespread disease however, there is not much information about its pathogenesis. However, with the advancement of molecular diagnostics, the PIK3R1 gene could be used to aid doctors in diagnosing the disease.
PIK3R1 is expressed by various human cancer types. Breast cancer patients have been proven to have a reduced expression of the p85a. This is due to the fact that it regulates stromal/epithelial crosstalk, which plays an important role in tumour growth. In addition, fibroblasts that express P85a/fibroblasts perform similar functions as CAFs. This new marker could be useful in research to aid in diagnosis, prognosis, and targeted therapy.
Researchers can submit their results to PIK3R1 markers for species-specific studies or applications. This is a method that is suitable for researchers across the world. Boster scientists can submit their findings and receive product credits. Boster's products can be used to test the PIK3R1 genes in a variety of applications. PIK3R1 is a key gene that regulates protein synthesis within the body.
The tumour's microenvironment regulates PIK3R1 gene transcription. Studies have shown that chromosomal instabilities could be a key factor in tumour growth. It also explains why genetically-transformed cancer cells appear in breast tumours. However, it should be remembered that breast cancer is a multifaceted disease in which abnormal function, protein expression, and protein expression contribute to the development of the cancer.
The PIK3R1 gene is a key player in many autoimmune diseases which include psoriasis and lupus and inflammatory bowel disorder. Its abnormal expression is often caused by an ineffective immune system and causes a severe inflammation response. The mutation leads to an early stop signal to translation and absent protein, which is the most expected result.
Numerous studies have revealed that metastasis from tumors is linked to PIK3R1 genes, including in MDAMB-231 and 4T1 cells as well as 4T1 cells. Western blot analysis of anti-S1 affinity purified IgG from week four samples has also confirmed that p85a/fibroblasts play a crucial role in metastasis. Therefore, a study to determine the PIK3R1 gene has been suggested for research into cancer.
PIK3R1 is a protein that is comprised of 724 amino acids . It also acts as a heterodimer with the catalytic unit of p110. It interacts with a range of proteins, including CCDC88A/GIV as well as CSF1R. It is activated in humans by ER stress.
The TK gene plays a key role in both antiviral and antitumor treatments. We don't have any structural information on the TK protein's wide substrate acceptance, which is essential to develop better nucleoside drugs and molecular models. Furthermore, HSV-1 TK serves as a suicide gene in antitumor treatment.
PIK3R1 is a major regulator of the immune cell response to herpes simplex virus infection. It regulates viral replication by preventing the transcription of key viral genes. When activated the PIK3R1 promoter regulates the activities of PIP3 and the Akt gene in eukaryotic cells.
Although the mechanism for this isn't certain, evidence has discovered that pAkt controls TNBC cells' expression of herpes simplex virus genes. The cells are affected by mutations in the Akt/PTEN pathway. Western analyses show that three TNBC cell lines (Hs578T, BT549 and MDA-MB-468) have low p-Akt basal activities. These cells showed increased pAkt activity after treatment with CF33.
In addition to HSV-1 Thymidine Kinase and mTORC1 kinase, mTORC1 (T3) also regulates eIF4E-binding proteins, which is a major in repressing host cell transcription. T3 also triggers PI3K gene transcription in differentiated human neuronal cells.
Studies of thyroid hormone have shown that patients with thyroid disorders have a higher chance of contracting HSV-1. Researchers believe that the action of thyroid hormones on these receptors could affect the immune response to HSV-1. These findings require further investigation. These findings could have implications for the treatment and prevention of herpes virus infections.
Researchers have discovered that miR106a-5p affects the expression of ESC in undifferentiated and differentiated human cell lines. They discovered that T3 altered the expression of 84 genes: 15 genes exhibited a decrease in expression and 22 showed an increase. The expression profiles of eIF4EBP1 genes were opposite in differentiated cells. eIF4E increased sevenfold, while eIF4EBP1 grew fivefold.
PIK3R1 is a new candidate for immunotherapy against cancer. It is a target for the thymidine kinase promoter of herpes simplexvirus type 1 (HSV-1tk) as well as other oncolytic viruses. These viral agents use different progenitors of the virus, including wild-type viruses and genetically modified ones.
The M032-HSV-1 adenovirus is a mixed oncolytic and immunomodulatory HSV-1. Its genome is comprised of seven species and 57 serotypes of human Ad. Figure 2 illustrates the principal change to the Ad genome. The virus is enterogenic through coxsackie-adenovirus receptors (CAR).
PMID: 1849461 by Skolnik E.Y., et al. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
PMID: 8628286 by Antonetti D.A., et al. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.
*More publications can be found for each product on its corresponding product page