This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
PIK3R1 Antibodies
AND PIK3R1 ELISA kits, PIK3R1 Proteins
Many biological assays use antibodies to detect PIK3R1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIK3R1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIK3R1 antibodies...
Designing a Western blot for PIK3R1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PIK3R1 Western Blot GuideDesigning an IHC experiment for PIK3R1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PIK3R1 IHC GuidePIK3R1 Infographic by Boster Bio
All PIK3R1 Products
Product
Figures
Specificity
Applications
Price
Anti-PI 3 Kinase p85 alpha/PIK3R1 Antibody Picoband®
26 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00318-1
100 μg/vial
Cat # A00318-1
100 μg/vial
Anti-PI3 Kinase p85 alpha Rabbit Monoclonal Antibody
10 Citations
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # M00318-2
100 μl/vial
Cat # M00318-2
100 μl/vial
Human, Mouse, Rat
WB
$370
Cat # PA1410
100 μg/vial
Cat # PA1410
100 μg/vial
Human, Mouse, Rat
WB
$370
Cat # M00318
100 μl
Cat # M00318
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2337
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2337
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
IHC, WB
$405
Cat # A00318Y467
100ul
Cat # A00318Y467
100ul
Human, Mouse, Rat
IF, WB
$405
Cat # A00318Y607
100ul
Cat # A00318Y607
100ul
Human, Mouse, Rat
IP, IF, IHC, WB
$405
Cat # A00318Y463
100ul
Cat # A00318Y463
100ul
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00318-3
20μL, 40μL, 100μL, 200μL
Cat # M00318-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$480
Cat # EKC1456
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1456
1 kit, containing one 96-well plate and all necessary reagents
Human
$628
Cat # LS005295
20 µg, 100 µg
Cat # LS005295
20 µg, 100 µg
Human, Mouse, Rat
IHC, WB
$370
Cat # P00318
100 μl/vial
Cat # P00318
100 μl/vial
PIK3R1 Overview
Facts about Phosphatidylinositol 3-kinase regulatory subunit alpha.
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429).
Gene Information
| Human | |
|---|---|
| Gene Name: | PIK3R1 |
| Uniprot: | P27986 |
| Entrez: | 5295 |
Family
| Belongs to: |
|---|
| PI3K p85 subunit family |
Alternative Names
GRB1; GRB1PI3-kinase subunit p85-alpha; p85; p85-ALPHA; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase, regulatory, 1; phosphatidylinositol 3-kinase-associated p-85 alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI 3Kinase p85 alpha; PI 3-Kinase p85 alpha; PI3K regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PIK3R1; PtdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory s
Molecular Weight
Mass (kDA):
83.598 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q13.1 |
| Sequence: | 5; NC_000005.10 (68215737..68301821) |
Tissue Specificity
Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
Diseases
- Malignant Neoplasms
- Neoplasms
- Diabetes Mellitus
- Insulin Resistance
- Diabetes Mellitus, Non-insulin-dependent
- Cell Transformation, Neoplastic
- Obesity
- Glioblastoma
- Cell Invasion
- Insulin Sensitivity
- Neoplasm Metastasis
- Carcinoma
- Brain Neoplasms
Pathways
- Cell Growth
- Secretion
- Cell Proliferation
- Cell Cycle
- Pathogenesis
- Insulin Secretion
- Cell Migration
- Aging
- Glucose Homeostasis
- Glycolysis
- Transport
- Hypersensitivity
- Translation
PTMs
- Phosphorylation
Research Areas
- Lipid and Metabolism
- Phospho-Specific
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIK3R1
bosterbio.com/bosterbio-gene-info-cards/PIK3R1
References
PMID: 1849461 by Skolnik E.Y., et al. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
PMID: 8628286 by Antonetti D.A., et al. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.
11 Publications of Boster PIK3R1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/or.2016.4757, SPOCK1 promotes the proliferation, migration and invasion of glioma cells throug...
- PubMed ID: 10.3892/mmr.2015.3393, Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and s...
- PubMed ID: 10.1080/09168451.2017.1356216, Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squam...
- PubMed ID: 10.1016/j.intimp.2011.12.004, Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF...
- PubMed ID: 10.1016/j.imlet.2015.04.007, Suppressive oligodeoxynucleotides induced tolerogenic plasmacytoid dendritic cel...
- PubMed ID: 10.1016/j.brainres.2021.147508, The calcimimetic R-568 attenuates subarachnoid hemorrhage-induced vasospasm thro...
- PubMed ID: -, Ren,K.,Chi,X.,Wu,T.et al.Preliminary Study on the Antibacterial and Cytotoxic Ef...
- PubMed ID: 33930376, Güleç İ, Şengelen A,Karagöz-Güzey F,Önay-Uçar E,Eren B,Vahabova G,Karaca...
- PubMed ID: 33930376, Güleç İ, Şengelen A,Karagöz-Güzey F,Önay-Uçar E,Eren B,Vahabova G,Karaca...
- PubMed ID: -, Lu Kong,Yongya Wu,Wangcheng Hu,Lin Liu,Yuying Xue,Geyu Liang,Mechanisms underlyi...
- PubMed ID: 28752099, Expressions Profiles of the Proteins Associated with Carbohydrate Metabolism in ...
*More publications can be found for each product on its corresponding product page