Prostaglandin G/H synthase 2 (PTGS2)

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in certain tissues in physiological conditions, like the endothelium, kidney and brain, and in pathological conditions, such as in cancer.

PTGS2 accounts for production of inflammatory prostaglandins. Up- regulation of PTGS2 is also correlated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis.