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- Table of Contents
SMAD5 Antibodies
AND SMAD5 ELISA kits, SMAD5 Proteins
Many biological assays use antibodies to detect SMAD5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMAD5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMAD5 antibodies...
Designing a Western blot for SMAD5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SMAD5 Western Blot GuideDesigning an IHC experiment for SMAD5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SMAD5 IHC GuideSMAD5 Infographic by Boster Bio
All SMAD5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P01423-1
100 μl
Cat # P01423-1
100 μl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01423
100 μl
Cat # M01423
100 μl
Human, Mouse, Rat
WB
$370
Cat # P01423
100 μl
Cat # P01423
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01423-2
20μL, 40μL, 100μL, 200μL
Cat # M01423-2
20μL, 40μL, 100μL, 200μL
SMAD5 Overview
Facts about Mothers against decapentaplegic homolog 5.
Mothers against decapentaplegic homolog 5 (SMAD5)
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
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Gene Information
| Human | |
|---|---|
| Gene Name: | SMAD5 |
| Uniprot: | Q99717 |
| Entrez: | 4090 |
Family
| Belongs to: |
|---|
| dwarfin/SMAD family |
Alternative Names
Dwfc; hSmad5; JV5-1; JV5-1DKFZp781O1323; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5 (Drosophila); MADH5; MADH5mothers against decapentaplegic homolog 5; mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; Mothers against DPP homolog 5; SMA- and MAD-related protein 5; SMAD 5; SMAD family member 5DKFZp781C1895; SMAD, mothers against DPP homolog 5 (Drosophila); SMAD, mothers against DPP homolog 5; Smad5
Molecular Weight
Mass (kDA):
52.258 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.1 |
| Sequence: | 5; NC_000005.10 (136132845..136182734) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tumor Angiogenesis
- Carcinoma
- Leukemia
- Myeloid Leukemia
- Malignant Paraganglionic Neoplasm
- Hypertensive Disease
- Cell Transformation, Neoplastic
- Tissue Adhesions
- Idiopathic Pulmonary Hypertension
- Pulmonary Hypertension
- Haploinsufficiency
Interacting Proteins
- DDX5
Pathways
- Cell Proliferation
- Osteoblast Differentiation
- Cell Differentiation
- Angiogenesis
- Gastrulation
- Pathogenesis
- Localization
- Bmp Signaling Pathway
- Cell Cycle
- Secretion
- Ossification
- Cell Growth
- Vasculogenesis
PTMs
- Phosphorylation
- Ubiquitination
- Dephosphorylation
Research Areas
- Phospho-Specific
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMAD5
bosterbio.com/bosterbio-gene-info-cards/SMAD5
References
PMID: 8673135 by Riggins G.J., et al. Mad-related genes in the human.
PMID: 9288787 by Hejlik D.P., et al. Localization of SMAD5 and its evaluation as a candidate myeloid tumor suppressor.