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- Table of Contents
SMAD9 Antibodies
AND SMAD9 ELISA kits, SMAD9 Proteins
Many biological assays use antibodies to detect SMAD9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMAD9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMAD9 antibodies...
Designing an IHC experiment for SMAD9? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SMAD9 IHC GuideSMAD9 Infographic by Boster Bio
All SMAD9 Products
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SMAD9 Overview
Facts about Mothers against decapentaplegic homolog 9.
Mothers against decapentaplegic homolog 9 (SMAD9)
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
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Gene Information
| Human | |
|---|---|
| Gene Name: | SMAD9 |
| Uniprot: | O15198 |
| Entrez: | 4093 |
Family
| Belongs to: |
|---|
| dwarfin/SMAD family |
Alternative Names
MAD homolog 9; MAD, mothers against decapentaplegic homolog 9 (Drosophila); Madh6; MADH6mothers against decapentaplegic homolog 9; MADH9; MADH9Mothers against decapentaplegic, drosophila, homolog of, 9; Mothers against DPP homolog 9; SMAD 9; SMAD family member 9SMAD8B; SMAD, mothers against DPP homolog 9 (Drosophila); SMAD, mothers against DPP homolog 9; SMAD8; SMAD8A; Smad9
Molecular Weight
Mass (kDA):
52.493 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q13.3 |
| Sequence: | 13; NC_000013.11 (36844831..36920721, complement) |
Tissue Specificity
Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.
Subcellular Localizations
Cytoplasm. Nucleus. In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).
Diseases
- Neoplasms
- Hereditary Hemochromatosis
- Tumor Angiogenesis
- Malignant Neoplasms
- Hemochromatosis
- Neoplasm Metastasis
- Infertility
- Carcinoma
- Inflammation
- Idiopathic Pulmonary Hypertension
- Pulmonary Hypertension
- Cell Transformation, Neoplastic
- Tissue Adhesions
Interacting Proteins
- KDM1A
- LEMD3
- PRMT6
Pathways
- Cell Proliferation
- Cell Differentiation
- Angiogenesis
- Cell Migration
- Osteoblast Differentiation
- Dna Methylation
- Senescence
- Methylation
- Endothelial Cell Migration
- Cell Death
- Pathogenesis
- Mullerian Duct Regression
- Programmed Cell Death
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMAD9
bosterbio.com/bosterbio-gene-info-cards/SMAD9
References
PMID: 9205116 by Watanabe T.K., et al. Cloning and characterization of a novel member of the human Mad gene family (MADH6).
PMID: 9759503 by Massague J.; TGF-beta signal transduction.