Greetings Earthling,

Download your Nanog Mammalian ESC Pluripotency Pathway and Alzheimer's Disease Pathway Maps below. Globally there are millions of people suffering from Alzheimer's Disease, learn more about this devastating illness today. Click the images below to download your pathway maps.

See related pathway antibodies in recommended products below!

Alzheimers Disease Brain

Troubleshooting Guides

Download troubleshootingnhandbooks for IHC, Western blot and ELISA for FREE.

troubleshooting_box_imageTroubleshooting guides

Alzheimer's Disease Pathway

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that progressively worsens and disables cognitive ability. Amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2), and apolipoprotein (ApoE) are associated with autosomal dominant or familial early onset AD (FAD).

When APP is produced, it is channeled through non-amyloidogenic or amyloidogenic pathways. Amyloid beta fibrils form a major component of senile plaques. They are known to trigger membrane lipid peroxidation and reactive oxygen species (ROS) production.

Alzheimers Disease Pathway

Nanog Mammalian ESC Pluripotency Pathway

Embryonic stem cells (ESCs) possess the special abilities for unlimited self-renewal and pluripotency. These properties are regulated by Nanog, Oct4, SOX2, and several other transcriptional factors. The Nanog protein is composed of 3 domains - the N-terminal, the homeodomain, and the C-terminal. Nanog expression only occurs in pluripotent cells where it promotes self-renewal after Oct4 and SOX2 bind to the Nanog promoter.

Nanog is also regulated by multiple pathways and pluripotent factors, such as FoxD3, the LIF/STAT pathway, WNT pathway, BMP pathway, PI3K/Akt pathway, and GRB2/SOS/Ras/ERK pathway. The exact mechanism of Nanog regulation and function is not fully understood yet.

Nanog Mammalian ESC Pluripotency Pathway

To download MORE pathways, click this button: Get more!

Buy Primary Antibody Get Secondary FREE

Buy Primary Antibody Get Secondary FREE

Recommended Products

Guaranteed to work as advertised or your money back! Click here to see our Boster Quality Guarantee: QUALITY GUARANTEE

See more

Boster Guarantee

All Boster antibodies and ELISA kits are guaranteed to meet the specifications on the data sheet. We promise to thoroughly investigate any concerns about the quality of our products; if you encounter a problem with a Boster antibody or ELISA kit, our technical support team will respond with personalized advice within 24 hours. If we can’t make your experiment work, we will refund your purchase in full or provide a replacement free of charge.

100% Satisfaction Guaranteed

Product Review

Anti-DISC1 Antibody (PA2023)

Review : "We tested several anti-DISC1 antibodies that are commercially available on the market. However, we found that this rabbit polyclonal anti-DISC1 antibody from Bosterbio company is the best one. We have used this antibody for IF, WB and IP purposes in NIH3T3 and Jurkat cell lines...The antibody detected a single band of protein at around 100 KD. Cheap, polyclonal, multipurpose use, fast shipping...The best DISC1 antibody in the market that can be used for IP, IF and WB." -Shubhankar Nath, UNIVERSITY OF TEXAS, GRADUATE STUDENT

Read More

About Boster Biological Technology

Here are some quick facts about



4.8 / 5
Rating on