Anti-Zinc finger MYM-type protein 2 ZMYM2 Antibody

Product Name

Anti-Zinc finger MYM-type protein 2 ZMYM2 Antibody

View all ZMYM2 Antibodies

SKU/Catalog Number

A04648

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Zinc finger MYM-type protein 2 ZMYM2 Antibody (Catalog # A04648). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

ZMYM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Zinc finger MYM-type protein 2 ZMYM2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04648)

Host

Rabbit

Contents

ZMYM2 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

ZMYM2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ZMYM2. The immunogen is located within amino acids 120 - 170 of ZMYM2.

Cross-reactivity

At least two isoforms of ZMYM2 are known to exist; this antibody will detect only the longest isoform. ZMYM2 antibody is predicted to not cross-react with other ZMYM protein family members.

Reactive Species

A04648 is reactive to ZMYM2 in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

154.9 kDa

Background of ZMYM2

Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression (1). The protein folding and the DNA binding ability are governed by the coordination of a zinc ion (1-3). As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes (4). Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL) (5).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A04648 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee

Recommend Dilution

ZMYM2 antibody can be used for detection of ZMYM2 by Western blot at 0. 125 - 0.25 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information ZMYM2

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