Anti-ACVR1C Antibody

Product Name

Anti-ACVR1C Antibody

View all ACVR1 Antibodies

SKU/Catalog Number

A00798-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-ACVR1C Antibody (Catalog # A00798-1). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

ACVR1C antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-ACVR1C Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00798-1)

Host

Rabbit

Contents

ACVR1C Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

ACVR1C antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human ACVR1C. The immunogen is located within amino acids 130 - 180 of ACVR1C.

Cross-reactivity

This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1B.

Reactive Species

A00798-1 is reactive to ACVR1 in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

57.2 kDa

Background of ACVR1

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A00798-1 is guaranteed for ELISA, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ACVR1C antibody can be used for detection of ACVR1C by Western blot at 1 and 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information ACVR1

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