Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband™

AGTR-1 antibody

Boster Bio Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband™ catalog # PB9470. Tested in IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. Cited in 2 publication(s).

Product Info Summary

SKU: PB9470
Size: 100 μg/vial
Reactive Species: Human, Monkey, Mouse, Rat
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband™

View all AGTR-1 Antibodies

SKU/Catalog Number

PB9470

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband™ catalog # PB9470. Tested in IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9470)

Host

Rabbit

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human AGTR1, different from the related mouse and rat sequences by one amino acid.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9470 is reactive to AGTR1 in Human, Monkey, Mouse, Rat

Applications

PB9470 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

50 kDa

Calculated molecular weight

41.061kDa

Background of AGTR-1

AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human, Monkey, Mouse, Rat

Validation Images & Assay Conditions

Gene/Protein Information For AGTR1 (Source: Uniprot.org, NCBI)

Gene Name

AGTR1

Full Name

Type-1 angiotensin II receptor

Weight

41.061kDa

Superfamily

G-protein coupled receptor 1 family

Alternative Names

AG2S; AGTR1; AGTR-1; AGTR1AAngiotensin II type-1 receptor; Angiostensin Receptor; angiotensin II receptor, type 1; angiotensin receptor 1; angiotensin receptor 1B; AT1; AT1AR; AT1AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1AGTR1B; AT2R1BAT1BR; HAT1R; type-1 angiotensin II receptor; type-1B angiotensin II receptor AGTR1 AG2SB, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R, AGTR1 angiotensin II receptor type 1 type-1 angiotensin II receptor|type-1B angiotensin II receptor

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on AGTR1, check out the AGTR1 Infographic

AGTR1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for AGTR1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PB9470 has been cited in 2 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Angiotensin II induces apoptosis of human pulmonary microvascular endothelial cells in acute aortic dissection complicated with lung injury patients through modulating the expression of monocyte chemoattractant protein-1

Effects of angiotensin II receptor antagonist, Losartan on the apoptosis, proliferation and migration of the human pancreatic stellate cells

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6 Customer Q&As for Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband™

Question

I see that the anti-Angiotensin II Type 1 Receptor/AGTR1 antibody PB9470 works with WB, what is the protocol used to produce the result images on the product page?

Verified Customer

Verified customer

Asked: 2020-05-05

Answer

You can find protocols for WB on the "support/technical resources" section of our navigation menu. If you have any further questions, please send an email to [email protected]

Boster Scientific Support

Answered: 2020-05-05

Question

I am interested in your PB9470 AGTR1 antibody, may I know if the antibody could be used with mouse and rat samples by WB and IHC? Please let me know if you have related information.

Verified Customer

Verified customer

Asked: 2019-12-06

Answer

We failed to get positive staining for IHC with mouse and rat samples. WB test result on rat samples was not good.

Boster Scientific Support

Answered: 2019-12-06

Question

My question regarding product PB9470, anti-Angiotensin II Type 1 Receptor/AGTR1 antibody. I was wondering if it would be possible to conjugate this antibody with biotin. I would need it to be without BSA or sodium azide. I am planning on using a buffer exchange of sodium azide with PBS only. Would there be problems for me to conjugate the antibody and store it in -20 degrees in small aliquots?

Z. Krishna

Verified customer

Asked: 2017-10-17

Answer

It is not recommended storing this antibody with PBS buffer only in -20 degrees. If you want to store it in -20 degrees it is best to add some cryoprotectant like glycerol. If you want carrier free PB9470 anti-Angiotensin II Type 1 Receptor/AGTR1 antibody, we can provide it to you in a special formula with trehalose and/or glycerol. These molecules will not interfere with conjugation chemistry and provide a good level of protection for the antibody from degradation. Please be sure to specify this in your purchase order.

Boster Scientific Support

Answered: 2017-10-17

Question

Do you have a BSA free version of anti-Angiotensin II Type 1 Receptor/AGTR1 antibody PB9470 available?

S. Brown

Verified customer

Asked: 2017-08-17

Answer

Thanks for your recent telephone inquiry. I can confirm that some lots of this anti-Angiotensin II Type 1 Receptor/AGTR1 antibody PB9470 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.

Boster Scientific Support

Answered: 2017-08-17

Question

I appreciate helping with my inquiry over the phone. Here are the WB image, lot number and protocol we used for liver using anti-Angiotensin II Type 1 Receptor/AGTR1 antibody PB9470. Let me know if you need anything else.

Verified Customer

Verified customer

Asked: 2017-05-16

Answer

Thanks for the data. You have provided everything we needed. Our lab team are working to resolve your inquiry as quickly as possible, and we appreciate your patience and understanding! Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2017-05-16

Question

We are currently using anti-Angiotensin II Type 1 Receptor/AGTR1 antibody PB9470 for human tissue, and we are happy with the WB results. The species of reactivity given in the datasheet says human, mouse. Is it true that the antibody can work on pig tissues as well?

L. Gonzalez

Verified customer

Asked: 2016-06-27

Answer

The anti-Angiotensin II Type 1 Receptor/AGTR1 antibody (PB9470) has not been validated for cross reactivity specifically with pig tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in pig you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2016-06-27

Size

Conjugation

Total: $370

SKU:PB9470

In stock, 3+ left.

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PB9470
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

$50 fee for conjugation. Antibody size is reduced to 50ug.

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