Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband®

Product Name

Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband®

View all AGTR1 Antibodies

SKU/Catalog Number

PB9470
PB0492 is an alternative SKU for this antibody, used in previous lots.

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband® catalog # PB9470. Tested in IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Angiotensin II Type 1 Receptor/AGTR1 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9470)

Host

Rabbit

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human AGTR1, different from the related mouse and rat sequences by one amino acid.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9470 is reactive to AGTR1 in Human, Monkey, Mouse, Rat

Observed Molecular Weight

50 kDa

Calculated molecular weight

41.1 kDa

Background of AGTR1

AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PB9470 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human
Western blot, 0.1-0.5μg/ml, Human, Monkey, Mouse, Rat

Positive Control

WB: human HEK293 whole cell, human T-47D whole cell, human PC-3 whole cell, human U-87MG whole cell, human HepG2 whole cell, monkey COS-7 whole cell, rat brain tissue, rat liver tissue, rat kidney tissue, rat RH35 whole cell, mouse brain tissue, mouse liver tissue, mouse kidney tissue, mouse HEPA1-6 whole cell
IHC: human mammary cancer tissue

Validation Images & Assay Conditions

See full target information AGTR1

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