Type-1 angiotensin II receptor (AGTR1)
Receptor for angiotensin II.
Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.
.
Gene Information
Human |
Gene Name: |
AGTR1 |
Uniprot: |
P30556 |
Entrez: |
185 |
Family
Belongs to: |
|
G-protein coupled receptor 1 family |
Alternative Names
AG2S; AGTR1; AGTR-1; AGTR1AAngiotensin II type-1 receptor; Angiostensin Receptor; angiotensin II receptor, type 1; angiotensin receptor 1; angiotensin receptor 1B; AT1; AT1AR; AT1AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1AGTR1B; AT2R1BAT1BR; HAT1R; type-1 angiotensin II receptor; type-1B angiotensin II receptor
Molecular Weight
Mass (kDA):
41.061 kDA
Genomic Context
|
Human |
|
Location: |
3q24 |
Sequence: |
3; NC_000003.12 (148697871..148743003) |
Tissue Specificity
Liver, lung, adrenal and adrenocortical adenomas.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Hypertensive Disease
- Cholangiocarcinoma
- Diabetes Mellitus
- Kidney Diseases
- Cardiovascular Diseases
- Diabetic Nephropathy
- Atherosclerosis
- Essential Hypertension
- Coronary Artery Disease
- Malignant Neoplasms
- Infarction
- Myocardial Infarction
- Dysequilibrium Syndrome
- Hypertrophy
- Inflammation
- Left Ventricular Hypertrophy
- Diabetes Mellitus, Non-insulin-dependent
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Heart Diseases
Interacting Proteins
- AGT
- APLNR
- ATP1B1
- CERS6
- DNAJC8
Pathways
- Pathogenesis
- Excretion
- Cell Proliferation
- Glomerular Filtration
- Vasoconstriction
- Angiogenesis
- Aging
- Cell Cycle
- Secretion
- Cell Adhesion
- Segmentation
- Transport
- Endothelial Cell Proliferation
- Vasodilation
- Tissue Remodeling
- Ossification
- Mammary Gland Development
- Rna Folding
- Chromatin Modification
- Estradiol Secretion
Best Uses Of The AGTR1 Marker From Boster Bio
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GTR1 Marker
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References
PMID: 1378723 by Mauzy C.A., et al. Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.
PMID: 1543512 by Furuta H., et al. Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.