Anti-c Abl/ABL1 Antibody Picoband™

c-Abl antibody

Boster Bio Anti-c Abl/ABL1 Antibody Picoband™ catalog # PB9468. Tested in WB applications. This antibody reacts with Human, Rat.

Product Info Summary

SKU: PB9468
Size: 100 μg/vial
Reactive Species: Human, Rat
Host: Rabbit
Application: WB

Product Name

Anti-c Abl/ABL1 Antibody Picoband™

View all c-Abl Antibodies

SKU/Catalog Number

PB9468

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-c Abl/ABL1 Antibody Picoband™ catalog # PB9468. Tested in WB applications. This antibody reacts with Human, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-c Abl/ABL1 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9468)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human c Abl, different from the related mouse sequence by one amino acid.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9468 is reactive to ABL1 in Human, Rat

Applications

PB9468 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

150 kDa

Calculated molecular weight

122.873kDa

Background of c-Abl

c Abl is also called as ABL1. This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t (9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene. Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat

Validation Images & Assay Conditions

Gene/Protein Information For ABL1 (Source: Uniprot.org, NCBI)

Gene Name

ABL1

Full Name

Tyrosine-protein kinase ABL1

Weight

122.873kDa

Superfamily

protein kinase superfamily

Alternative Names

Abelson murine leukemia viral oncogene homolog 1; ABL; ABL1; bcr/abl; BCR-ABL1; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; cAbl; c-Abl; EC 2.7.10; EC 2.7.10.2; JTK7; JTK7bcr/abl; p150bcr/c-abl oncogene protein; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1; v-abl ABL1 ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl ABL proto-oncogene 1, non-receptor tyrosine kinase tyrosine-protein kinase ABL1|ABL protooncogene 1 nonreceptor tyrosine kinase|Abelson tyrosine-protein kinase 1|bcr/c-abl oncogene protein|c-abl oncogene 1, receptor tyrosine kinase|proto-oncogene c-Abl|proto-oncogene tyrosine-protein kinase ABL1|truncated ABL protooncogene 1 nonreceptor tyrosine kinase|v-abl Abelson murine leukemia viral oncogene homolog 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ABL1, check out the ABL1 Infographic

ABL1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ABL1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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6 Customer Q&As for Anti-c Abl/ABL1 Antibody Picoband™

Question

Does anti-c Abl/ABL1 antibody PB9468 work on canine WB with cervix carcinoma erythroleukemia?

Verified Customer

Verified customer

Asked: 2020-04-22

Answer

Our lab technicians have not validated anti-c Abl/ABL1 antibody PB9468 on canine. You can run a BLAST between canine and the immunogen sequence of anti-c Abl/ABL1 antibody PB9468 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated canine samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in canine cervix carcinoma erythroleukemia in WB, you can get your next antibody for free.

Boster Scientific Support

Answered: 2020-04-22

Question

See below the WB image, lot number and protocol we used for lung using anti-c Abl/ABL1 antibody PB9468. Please let me know if you require anything else.

Verified Customer

Verified customer

Asked: 2019-11-25

Answer

Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2019-11-25

Question

Is a blocking peptide available for product anti-c Abl/ABL1 antibody (PB9468)?

Verified Customer

Verified customer

Asked: 2019-10-21

Answer

We do provide the blocking peptide for product anti-c Abl/ABL1 antibody (PB9468). If you would like to place an order for it please contact [email protected] and make a special request.

Boster Scientific Support

Answered: 2019-10-21

Question

We are currently using anti-c Abl/ABL1 antibody PB9468 for human tissue, and we are well pleased with the WB results. The species of reactivity given in the datasheet says human, rat. Is it true that the antibody can work on dog tissues as well?

E. Parker

Verified customer

Asked: 2019-03-04

Answer

The anti-c Abl/ABL1 antibody (PB9468) has not been tested for cross reactivity specifically with dog tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in dog you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-03-04

Question

Would anti-c Abl/ABL1 antibody PB9468 work for WB with lung?

Verified Customer

Verified customer

Asked: 2018-11-12

Answer

According to the expression profile of lung, ABL1 is highly expressed in lung. So, it is likely that anti-c Abl/ABL1 antibody PB9468 will work for WB with lung.

Boster Scientific Support

Answered: 2018-11-12

Question

Would PB9468 anti-c Abl/ABL1 antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?

T. Singh

Verified customer

Asked: 2018-09-28

Answer

It shows on the product datasheet, PB9468 anti-c Abl/ABL1 antibody as been validated on WB. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.

Boster Scientific Support

Answered: 2018-09-28

Size

Conjugation

Total: $370

SKU:PB9468

In stock, 2 left.

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PB9468
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

$50 fee for conjugation. Antibody size is reduced to 50ug.

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