Tyrosine-protein kinase ABL1 (ABL1)

Non-receptor tyrosine-protein kinase that plays a role in several key processes linked to cell growth and survival like cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins).

Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility via phosphorylation of key regulators of these processes like BCAR1, CRK, CRKL, DOK1, EFS or NEDD9.