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Product Info Summary
| SKU: | MA1019 |
|---|---|
| Size: | 100μg/vial |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | WB |
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Product info
Product Name
Anti-CDC6 Antibody (Monoclonal, DCS-180)
SKU/Catalog Number
MA1019
Size
100μg/vial
Form
Lyophilized
Description
Boster Bio Anti-CDC6 Antibody (Monoclonal, DCS-180) catalog # MA1019. Tested in WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-CDC6 Antibody (Monoclonal, DCS-180) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1019)
Host
Mouse
Contents
Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Clonality
Monoclonal
Clone Number
DCS-180
Isotype
Mouse IgG1
Immunogen
Recombinant human Cdc6.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross Reactivity
No cross reactivity with other proteins
Reactive Species
MA1019 is reactive to Cdc6 in Human
Applications
MA1019 is guaranteed for WB Boster Guarantee
Background of Cdc6
In yeasts, Cdc6 (Saccharomyces cerevisiae) and Cdc18 (Schizosaccharomyces pombe) associate with the origin recognition complex (ORC) proteins to render cells competent for DNA replication. Cdc6 is overexpressed in human cancers, where it has a critical regulatory role in addition to DNA replication. Yan et al. (1998) showed that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues in intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. They conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.
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Assay dilution & Images
Reconsitution
Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.
Western blot, 1-2μg/ml, Human
Validation Images & Assay Conditions
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Boster Kit Box
Protein Target Info & Infographic
Gene/Protein Information For Cdc6 (Source: Uniprot.Org, NCBI)
Uniprot ID
O89033
Gene ID
23834
Gene Name
Cdc6
Full Name
Cell division control protein 6 homolog
Weight
62.614kDa
Superfamily
CDC6/cdc18 family
Alternative Names
CDC18LHsCDC18; Cdc18-related protein; CDC6 (cell division cycle 6, S. cerevisiae) homolog; CDC6 cell division cycle 6 homolog (S. cerevisiae); CDC6 cell division cycle 6 homolog; CDC6-related protein; cell division control protein 6 homolog; cell division cycle 6 homolog (S. cerevisiae); cell division cycle 6 protein; HsCdc18; HsCDC6; p62(cdc6) Cdc6|CDC18, CDC18L, p62(cdc6)|cell division cycle 6|cell division control protein 6 homolog|CDC6-related protein|cell division cycle 6 homolog
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".For more info on Cdc6, check out the Cdc6 Infographic
We have 30,000+ of these available, one for each gene! check them out.
In this infographic you will see the following information for Cdc6: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]
Specific Publications For Anti-CDC6 Antibody (Monoclonal, DCS-180) (MA1019)
No publications found for MA1019
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