Anti-CDC6 Antibody (Monoclonal, DCS-180)

Cdc6 antibody

Boster Bio Anti-CDC6 Antibody (Monoclonal, DCS-180) catalog # MA1019. Tested in WB applications. This antibody reacts with Human.

Product Info Summary

SKU: MA1019
Size: 100μg/vial
Reactive Species: Human
Host: Mouse
Application: WB

Product Name

Anti-CDC6 Antibody (Monoclonal, DCS-180)

View all Cdc6 Antibodies

SKU/Catalog Number

MA1019

Size

100μg/vial

Form

Lyophilized

Description

Boster Bio Anti-CDC6 Antibody (Monoclonal, DCS-180) catalog # MA1019. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CDC6 Antibody (Monoclonal, DCS-180) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1019)

Host

Mouse

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

Clonality

Monoclonal

Clone Number

DCS-180

Isotype

Mouse IgG1

Immunogen

Recombinant human Cdc6.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross Reactivity

No cross reactivity with other proteins

Reactive Species

MA1019 is reactive to Cdc6 in Human

Applications

MA1019 is guaranteed for WB Boster Guarantee

Background of Cdc6

In yeasts, Cdc6 (Saccharomyces cerevisiae) and Cdc18 (Schizosaccharomyces pombe) associate with the origin recognition complex (ORC) proteins to render cells competent for DNA replication. Cdc6 is overexpressed in human cancers, where it has a critical regulatory role in addition to DNA replication. Yan et al. (1998) showed that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues in intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. They conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Reconsitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Western blot, 1-2μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For Cdc6 (Source: Uniprot.Org, NCBI)

Uniprot ID

O89033

Gene ID

23834

Gene Name

Cdc6

Full Name

Cell division control protein 6 homolog

Weight

62.614kDa

Superfamily

CDC6/cdc18 family

Alternative Names

CDC18LHsCDC18; Cdc18-related protein; CDC6 (cell division cycle 6, S. cerevisiae) homolog; CDC6 cell division cycle 6 homolog (S. cerevisiae); CDC6 cell division cycle 6 homolog; CDC6-related protein; cell division control protein 6 homolog; cell division cycle 6 homolog (S. cerevisiae); cell division cycle 6 protein; HsCdc18; HsCDC6; p62(cdc6) Cdc6|CDC18, CDC18L, p62(cdc6)|cell division cycle 6|cell division control protein 6 homolog|CDC6-related protein|cell division cycle 6 homolog

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on Cdc6, check out the Cdc6 Infographic

Cdc6 infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for Cdc6: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

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Size

Total: $315

SKU:MA1019

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MA1019
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$315.00

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